Superoxides

Rac family small GTPase 1 ; Homo sapiens







76 Article(s)
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1 30760703 Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas. 2019 Feb 13 2
2 31103719 A feedforward relationship between active Rac1 and phosphorylated Bcl-2 is critical for sustaining Bcl-2 phosphorylation and promoting cancer progression. 2019 Aug 10 3
3 31736979 The Prolyl Isomerase Pin1 Controls Lipopolysaccharide-Induced Priming of NADPH Oxidase in Human Neutrophils. 2019 1
4 29321004 RCC2 over-expression in tumor cells alters apoptosis and drug sensitivity by regulating Rac1 activation. 2018 Jan 10 1
5 27380944 Stochastic modelling suggests that an elevated superoxide anion - hydrogen peroxide ratio can drive extravascular phagocyte transmigration by lamellipodium formation. 2016 Oct 21 2
6 27437916 17-β-estradiol Decreases Neutrophil Superoxide Production through Rac1. 2016 Nov 2
7 27638049 ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis. 2016 Nov 1 1
8 25874999 Correction: Ras and Rac1, frequently mutated in melanomas, are activated by superoxide anion, modulate Dnmt1 level and are causally related to melanocyte malignant transformation. 2015 1
9 25056956 Arachidonic acid induces direct interaction of the p67(phox)-Rac complex with the phagocyte oxidase Nox2, leading to superoxide production. 2014 Sep 5 1
10 23559002 Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases. 2013 Apr 4 1
11 23792701 Rac1 and cholesterol metabolism in macrophage. 2013 Nov 1
12 24358134 Ras and Rac1, frequently mutated in melanomas, are activated by superoxide anion, modulate Dnmt1 level and are causally related to melanocyte malignant transformation. 2013 3
13 22098189 NADPH oxidase 1-mediated oxidative stress leads to dopamine neuron death in Parkinson's disease. 2012 May 15 1
14 22144277 Assessment of the role for Rho family GTPases in NADPH oxidase activation. 2012 3
15 22192670 Myocardial redox state predicts in-hospital clinical outcome after cardiac surgery effects of short-term pre-operative statin treatment. 2012 Jan 3 1
16 22965909 Crumbs limits oxidase-dependent signaling to maintain epithelial integrity and prevent photoreceptor cell death. 2012 Sep 17 1
17 21037555 Role of Rac1-dependent NADPH oxidase in the growth of pancreatic cancer. 2011 Feb 2
18 21474673 The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity. 2011 Jun 9 3
19 19923407 Rac1 mediates NaCl-induced superoxide generation in the thick ascending limb. 2010 Feb 3
20 20074642 Characterization of P-Rex1 for its role in fMet-Leu-Phe-induced superoxide production in reconstituted COS(phox) cells. 2010 May 1
21 20529851 A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity. 2010 Aug 13 1
22 20844008 Rac1-dependent intracellular superoxide formation mediates vascular endothelial growth factor-induced placental angiogenesis in vitro. 2010 Nov 2
23 19497305 Inhibitory effect of estrogen on Rac1-expression in monocytes. 2009 Aug 14 2
24 19625648 Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2. 2009 Aug 15 1
25 18160398 Stimulus-dependent regulation of the phagocyte NADPH oxidase by a VAV1, Rac1, and PAK1 signaling axis. 2008 Mar 21 1
26 18424721 Inorganic arsenic activates reduced NADPH oxidase in human primary macrophages through a Rho kinase/p38 kinase pathway. 2008 May 1 1
27 18518859 Activation of NADPH oxidase 1 in tumour colon epithelial cells. 2008 Oct 1 9
28 18658277 Endothelial cell barrier protection by simvastatin: GTPase regulation and NADPH oxidase inhibition. 2008 Oct 1
29 18660830 Superoxide from NADPH oxidase upregulates type 5 phosphodiesterase in human vascular smooth muscle cells: inhibition with iloprost and NONOate. 2008 Nov 3
30 18678787 Roles of phosphatidylinositol 3-kinase-Akt and NADPH oxidase in adenosine 5'-triphosphate-sensitive K+ channel function impaired by high glucose in the human artery. 2008 Sep 1
31 18759927 Regulation of B-cell entry into the cell cycle. 2008 Aug 1
32 17101842 Mycophenolate acid inhibits endothelial NAD(P)H oxidase activity and superoxide formation by a Rac1-dependent mechanism. 2007 Jan 1
33 17548354 Tripartite chimeras comprising functional domains derived from the cytosolic NADPH oxidase components p47phox, p67phox, and Rac1 elicit activator-independent superoxide production by phagocyte membranes: an essential role for anionic membrane phospholipids. 2007 Jul 27 2
34 17583407 Role of the small GTPase Rac in p22phox-dependent NADPH oxidases. 2007 Sep 2
35 17854274 MKK6 phosphorylation regulates production of superoxide by enhancing Rac GTPase activity. 2007 Nov 1
36 16354686 Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes. 2006 Jan 1
37 16670255 Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy. 2006 Aug 16 1
38 16762923 Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1. 2006 Aug 4 2
39 17128987 Redox regulation of RhoA. 2006 Dec 5 1
40 15504745 Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo. Role of the C-terminal polybasic domain. 2005 Jan 14 1
41 15569826 Atrial natriuretic peptide induces mitogen-activated protein kinase phosphatase-1 in human endothelial cells via Rac1 and NAD(P)H oxidase/Nox2-activation. 2005 Jan 7 2
42 15941833 Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase. 2005 Jun 21 2
43 16081809 Isoform-specific membrane targeting mechanism of Rac during Fc gamma R-mediated phagocytosis: positive charge-dependent and independent targeting mechanism of Rac to the phagosome. 2005 Aug 15 1
44 15170212 Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils. 2004 Jul 1
45 12606638 Rac1 and superoxide are required for the expression of cell adhesion molecules induced by tumor necrosis factor-alpha in endothelial cells. 2003 May 1
46 12894215 Decrease in intracellular superoxide sensitizes Bcl-2-overexpressing tumor cells to receptor and drug-induced apoptosis independent of the mitochondria. 2003 Nov 1
47 11896053 Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent. 2002 May 24 1
48 11896062 A prenylated p67phox-Rac1 chimera elicits NADPH-dependent superoxide production by phagocyte membranes in the absence of an activator and of p47phox: conversion of a pagan NADPH oxidase to monotheism. 2002 May 24 1
49 12411394 Rac-dependent monocyte chemoattractant protein-1 production is induced by nutrient deprivation. 2002 Nov 1 1
50 12471136 Repression of rac2 mRNA expression by Anaplasma phagocytophila is essential to the inhibition of superoxide production and bacterial proliferation. 2002 Dec 15 1