Title : The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity.

Pub. Date : 2011 Jun 9

PMID : 21474673






3 Functional Relationships(s)
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1 The small GTPase Rac1 is involved in the activation of the reduced NAD phosphate oxidase complex resulting in superoxide production. Superoxides Rac family small GTPase 1 Homo sapiens
2 We report here that silencing and functional inhibition of Rac1 block Bcl-2-mediated increase in intracellular superoxide levels in tumor cells. Superoxides Rac family small GTPase 1 Homo sapiens
3 That this interaction is functionally relevant is supported by the ability of the Bcl-2 BH3 peptide as well as the silencing and functional inhibition of Rac1 to inhibit intracellular superoxide production as well as overcome Bcl-2-mediated drug resistance in human leukemia cells and cervical cancer cells. Superoxides Rac family small GTPase 1 Homo sapiens