Title : Superoxide from NADPH oxidase upregulates type 5 phosphodiesterase in human vascular smooth muscle cells: inhibition with iloprost and NONOate.

Pub. Date : 2008 Nov

PMID : 18660830






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The role of Rac(1) in superoxide generation was assessed by overexpressing either the dominant-negative or constitutively active Rac isoforms. Superoxides Rac family small GTPase 1 Homo sapiens
2 The role of Rac(1) in superoxide generation was assessed by overexpressing either the dominant-negative or constitutively active Rac isoforms. Superoxides Rac family small GTPase 1 Homo sapiens
3 Overexpression of dominant-negative Rac(1) or addition of iloprost, DETA-NONOate or Y27632 completely blocked both superoxide release and PDE5 protein expression and activity. Superoxides Rac family small GTPase 1 Homo sapiens