Pub. Date : 2012
PMID : 22144277
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rac, a member of the Rho family small GTPases, plays a crucial role in activation of Nox family NADPH oxidases in animals, enzymes dedicated to production of reactive oxygen species such as superoxide. | Superoxides | Rac family small GTPase 1 | Homo sapiens |
| 2 | Rac in the GTP-bound form directly binds to the oxidase activator p67( phox ), which in turn interacts with Nox2, leading to superoxide production. | Superoxides | Rac family small GTPase 1 | Homo sapiens |
| 3 | On the other hand, in the presence of either p67( phox ) or Noxa1, Rac facilitates superoxide production by Nox3, which is responsible in the inner ear for formation of otoconia, tiny mineralized structures that are required for sensing balance and gravity. | Superoxides | Rac family small GTPase 1 | Homo sapiens |