Title : Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases.

Pub. Date : 2013 Apr 4

PMID : 23559002






1 Functional Relationships(s)
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1 We also show that the unprenylated RhoA- and Rac1-GTP retained at least part of their functional activities, as evidenced by the increase in intracellular superoxide production and JNK activation in response to simvastatin. Superoxides Rac family small GTPase 1 Homo sapiens