Title : Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases.

Pub. Date : 2013 Apr 4

PMID : 23559002

1 Functional Relationships(s)
Compound Name
Protein Name
1 We also show that the unprenylated RhoA- and Rac1-GTP retained at least part of their functional activities, as evidenced by the increase in intracellular superoxide production and JNK activation in response to simvastatin. Superoxides Rac family small GTPase 1 Homo sapiens