Title : Rac1 mediates NaCl-induced superoxide generation in the thick ascending limb.

Pub. Date : 2010 Feb

PMID : 19923407






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Rac1 mediates NaCl-induced superoxide generation in the thick ascending limb. Superoxides Rac family small GTPase 1 Homo sapiens
2 We hypothesized that increasing luminal NaCl within the physiological range activates Rac1 and NADPH oxidase and, thereby, increases O(2)(-) production. Superoxides Rac family small GTPase 1 Homo sapiens
3 Similarly, in vivo treatment of TALs with adenovirus expressing dominant-negative Rac1 decreased NaCl-induced O(2)(-) generation by 60% compared with control (0.33 +/- 0.04 vs. 0.81 +/- 0.17 nmol O(2)(-) x min(-1) x mg protein(-1), n = 6, P < 0.05). Superoxides Rac family small GTPase 1 Homo sapiens