Sirolimus

ribosomal protein S6 kinase B1 ; Homo sapiens







298 Article(s)
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51 30219159 Silent Information Regulator 1 Negatively Regulates Atherosclerotic Angiogenesis via Mammalian Target of Rapamycin Complex 1 Signaling Pathway. 2018 Aug 1
52 30317760 [Comparison of effects of oleic acid and palmitic acid on lipid deposition and mTOR / S6K1 / SREBP-1c pathway in HepG2 cells]. 2018 Jun 20 1
53 30416863 URI knockdown induces autophagic flux in gastric cancer cells. 2018 1
54 27993682 Trastuzumab stimulation of ribosomal protein S6 kinase 1 (S6K1) predicts de novo trastuzumab resistance. 2017 Jan 29 1
55 28243129 Polydatin regulates proliferation, apoptosis and autophagy in multiple myeloma cells through mTOR/p70s6k pathway. 2017 1
56 28446743 Mammalian Target of Rapamycin (mTOR) Regulates Transforming Growth Factor-β1 (TGF-β1)-Induced Epithelial-Mesenchymal Transition via Decreased Pyruvate Kinase M2 (PKM2) Expression in Cervical Cancer Cells. 2017 Apr 27 1
57 28487599 miR-195 Regulates Proliferation and Apoptosis through Inhibiting the mTOR/p70s6k Signaling Pathway by Targeting HMGA2 in Esophageal Carcinoma Cells. 2017 1
58 28559962 Icariside II promotes the osteogenic differentiation of canine bone marrow mesenchymal stem cells via the PI3K/AKT/mTOR/S6K1 signaling pathways. 2017 1
59 28765952 mTOR signaling promotes foam cell formation and inhibits foam cell egress through suppressing the SIRT1 signaling pathway. 2017 Sep 1
60 28831455 Inhibition of p70S6K does not mimic the enhancement of Akt phosphorylation by rapamycin. 2017 Aug 1
61 28963126 EGF regulation of proximal tubule cell proliferation and VEGF-A secretion. 2017 Sep 3
62 29163161 Inhibition of miR-128-3p by Tongxinluo Protects Human Cardiomyocytes from Ischemia/reperfusion Injury via Upregulation of p70s6k1/p-p70s6k1. 2017 1
63 26740621 Ubiquilin-mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling. 2016 Mar 4 1
64 26752047 Rapamycin Inhibits Oxidized Low Density Lipoprotein Uptake in Human Umbilical Vein Endothelial Cells via mTOR/NF-κB/LOX-1 Pathway. 2016 1
65 26943752 Resveratrol Potentiates Growth Inhibitory Effects of Rapamycin in PTEN-deficient Lipoma Cells by Suppressing p70S6 Kinase Activity. 2016 2
66 27070592 Distinct Dasatinib-Induced Mechanisms of Apoptotic Response and Exosome Release in Imatinib-Resistant Human Chronic Myeloid Leukemia Cells. 2016 Apr 8 1
67 27167250 The ERK1/2 and mTORC1 Signaling Pathways Are Involved in the Muscarinic Acetylcholine Receptor-Mediated Proliferation of SNU-407 Colon Cancer Cells. 2016 Dec 2
68 27438654 Unique and Redundant Functions of p70 Ribosomal S6 Kinase Isoforms Regulate Mesenchymal Cell Proliferation and Migration in Pulmonary Fibrosis. 2016 Dec 2
69 27595116 Downregulation of p70S6K Enhances Cell Sensitivity to Rapamycin in Esophageal Squamous Cell Carcinoma. 2016 7
70 25659819 Rapamycin-induced G1 cell cycle arrest employs both TGF-β and Rb pathways. 2015 May 1 3
71 25663935 FOXP1 regulation via the PI3K/Akt/p70S6K signaling pathway in breast cancer cells. 2015 Mar 1
72 25698201 P70S6 kinase phosphorylation: a new site to assess pharmacodynamy of sirolimus. 2015 Mar 5 5
73 25767889 TORC1 promotes phosphorylation of ribosomal protein S6 via the AGC kinase Ypk3 in Saccharomyces cerevisiae. 2015 1
74 25813876 Alpha-synuclein overexpression negatively regulates insulin receptor substrate 1 by activating mTORC1/S6K1 signaling. 2015 Jul 2
75 25903737 Interleukin-1β plays a role in the pathogenesis of mesial temporal lobe epilepsy through the PI3K/Akt/mTOR signaling pathway in hippocampal neurons. 2015 May 15 1
76 25988388 Suppression of the proliferation of hypoxia-Induced retinal pigment epithelial cell by rapamycin through the /mTOR/HIF-1α/VEGF/ signaling. 2015 Jun 1
77 26002629 Rapamycin prevents cadmium-induced neuronal cell death via targeting both mTORC1 and mTORC2 pathways. 2015 Oct 2
78 26046470 Intracellular sirolimus concentration is reduced by tacrolimus in human pancreatic islets in vitro. 2015 Oct 1
79 26251974 Cyclic mechanical stretch promotes energy metabolism in osteoblast-like cells through an mTOR signaling-associated mechanism. 2015 Oct 1
80 26362858 Rapamycin restores p14, p15 and p57 expression and inhibits the mTOR/p70S6K pathway in acute lymphoblastic leukemia cells. 2015 Nov 1
81 26367731 Rapamycin inhibits the proliferation of SW1990 pancreatic cancer cell. 2015 Aug 1
82 26887615 [Sensitivity of esophageal squamous cell carcinoma cells to rapamycin can be improved by siRNA-interfered expression of p70S6K]. 2015 Dec 3
83 24076964 Regulation of matrix metalloproteinase-1, -3, and -9 in Mycobacterium tuberculosis-dependent respiratory networks by the rapamycin-sensitive PI3K/p70(S6K) cascade. 2014 Jan 1
84 24239466 Dual inhibition by S6K1 and Elf4E is essential for controlling cellular growth and invasion in bladder cancer. 2014 Jan 3
85 24462769 Gβγ interacts with mTOR and promotes its activation. 2014 Feb 7 1
86 24508654 mTOR inhibition of cardamonin on antiproliferation of A549 cells is involved in a FKBP12 independent fashion. 2014 Mar 18 1
87 24630930 Catalase expression in MCF-7 breast cancer cells is mainly controlled by PI3K/Akt/mTor signaling pathway. 2014 May 15 1
88 24682932 Rapamycin combined with celecoxib enhanced antitumor effects of mono treatment on chronic myelogenous leukemia cells through downregulating mTOR pathway. 2014 Jul 2
89 24901052 Rapamycin-enhanced mitomycin C-induced apoptotic death is mediated through the S6K1-Bad-Bak pathway in peritoneal carcinomatosis. 2014 Jun 5 1
90 24916432 The mammalian target of rapamycin pathway in the basolateral amygdala is critical for nicotine-induced behavioural sensitization. 2014 Nov 1
91 24922651 Effects of targeting endometrial stromal sarcoma cells via histone deacetylase and PI3K/AKT/mTOR signaling. 2014 Jun 1
92 24936148 Activation of the PI3K/Akt/mTOR/p70S6K pathway is involved in S100A4-induced viability and migration in colorectal cancer cells. 2014 1
93 25149531 Tuberin-deficiency downregulates N-cadherin and upregulates vimentin in kidney tumor of TSC patients. 2014 Aug 30 1
94 25270513 Topical rapamycin systematically suppresses the early stages of pulsed dye laser-induced angiogenesis pathways. 2014 Nov 2
95 25324684 Interplay of autophagy and apoptosis during murine cytomegalovirus infection of RPE cells. 2014 2
96 25379021 Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K and RPS6 activation. 2014 Oct 1
97 25587030 Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion. 2014 Dec 30 2
98 22391570 S6K1 determines the metabolic requirements for BCR-ABL survival. 2013 Jan 24 1
99 23261705 Stimulatory effect of insulin on theca-interstitial cell proliferation and cell cycle regulatory proteins through MTORC1 dependent pathway. 2013 Feb 5 1
100 23273915 S6K1 alternative splicing modulates its oncogenic activity and regulates mTORC1. 2013 Jan 31 1