Title : S6K1 alternative splicing modulates its oncogenic activity and regulates mTORC1.

Pub. Date : 2013 Jan 31

PMID : 23273915






1 Functional Relationships(s)
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1 Both a phosphorylation-defective 4E-BP1 mutant and the mTORC1 inhibitor rapamycin partially blocked the oncogenic effects of S6K1 short isoforms, suggesting that these are mediated by mTORC1 and 4E-BP1. Sirolimus ribosomal protein S6 kinase B1 Homo sapiens