Title : Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K and RPS6 activation.

Pub. Date : 2014 Oct

PMID : 25379021






1 Functional Relationships(s)
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1 Pharmacological inhibition of p70S6K using the PI3K/mTOR inhibitor NVP-BEZ235, the specific mTOR inhibitor Rapamycin and the specific p70S6K inhibitor PF-4708671 potentiated Selumetinib effects in resistant cells. Sirolimus ribosomal protein S6 kinase B1 Homo sapiens