Title : Rapamycin combined with celecoxib enhanced antitumor effects of mono treatment on chronic myelogenous leukemia cells through downregulating mTOR pathway.

Pub. Date : 2014 Jul

PMID : 24682932






2 Functional Relationships(s)
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1 Western blot and reverse transcription PCR (RT-PCR) analysis showed that the expressions of mTOR, 4E-BP1, and p70S6K were all significantly decreased in K562 cells after rapamycin + celecoxib treatment (P < 0.05). Sirolimus ribosomal protein S6 kinase B1 Homo sapiens
2 In conclusion, rapamycin combined with celecoxib could induce cell cycle arrest and apoptosis and decrease the expressions of mTOR, 4E-BP1, and p70S6K. Sirolimus ribosomal protein S6 kinase B1 Homo sapiens