Title : Rapamycin prevents cadmium-induced neuronal cell death via targeting both mTORC1 and mTORC2 pathways.

Pub. Date : 2015 Oct

PMID : 26002629






2 Functional Relationships(s)
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1 Coincidently, rapamycin markedly blocked Cd-induced phosphorylation of Akt, S6K1 and 4E-BP1 in the cells. Sirolimus ribosomal protein S6 kinase B1 Homo sapiens
2 Furthermore, downregulation of S6K1, ectopic expression of constitutively hypophosphorylated 4E-BP1 or dominant negative Akt, or co-treatment with Akt inhibitor also potentiated the rapamycin"s inhibitory effect. Sirolimus ribosomal protein S6 kinase B1 Homo sapiens