Pub. Date : 2016
PMID : 27595116
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Downregulation of p70S6K Enhances Cell Sensitivity to Rapamycin in Esophageal Squamous Cell Carcinoma. | Sirolimus | ribosomal protein S6 kinase B1 | Homo sapiens |
| 2 | It has been demonstrated that mTOR/p70S6K pathway was abnormally activated in many cancers and rapamycin and its analogs can restrain tumor growth through inhibiting this pathway, but some tumors including esophageal squamous cell carcinoma (ESCC) appear to be insensitive to rapamycin in recent studies. | Sirolimus | ribosomal protein S6 kinase B1 | Homo sapiens |
| 3 | The results showed that, after downregulating the expression of p70S6K and p-p70S6K by p70S6K siRNA, the inhibitory effects of rapamycin on cell proliferation, cell cycle, and tumor growth were significantly enhanced in vitro and in vivo. | Sirolimus | ribosomal protein S6 kinase B1 | Homo sapiens |
| 4 | The results showed that, after downregulating the expression of p70S6K and p-p70S6K by p70S6K siRNA, the inhibitory effects of rapamycin on cell proliferation, cell cycle, and tumor growth were significantly enhanced in vitro and in vivo. | Sirolimus | ribosomal protein S6 kinase B1 | Homo sapiens |
| 5 | The results showed that, after downregulating the expression of p70S6K and p-p70S6K by p70S6K siRNA, the inhibitory effects of rapamycin on cell proliferation, cell cycle, and tumor growth were significantly enhanced in vitro and in vivo. | Sirolimus | ribosomal protein S6 kinase B1 | Homo sapiens |
| 6 | These results indicated that p-p70S6K may participate in the invasion and metastasis in the development of ESCC and downregulation of the expression of p-p70S6K could improve the sensitivity of cells to rapamycin in ESCC. | Sirolimus | ribosomal protein S6 kinase B1 | Homo sapiens |
| 7 | These results indicated that p-p70S6K may participate in the invasion and metastasis in the development of ESCC and downregulation of the expression of p-p70S6K could improve the sensitivity of cells to rapamycin in ESCC. | Sirolimus | ribosomal protein S6 kinase B1 | Homo sapiens |