mitogen-activated protein kinase kinase kinase 5 ; Homo sapiens






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51 14764578 Oxidant hypersensitivity of Fanconi anemia type C-deficient cells is dependent on a redox-regulated apoptotic pathway. J Biol Chem 2004 Apr 16 4
52 15003321 Activation of c-Jun N-terminal kinase in A549 lung carcinoma cells by sodium dichromate: role of dissociation of apoptosis signal regulating kinase-1 from its physiological inhibitor thioredoxin. Toxicology 2004 Apr 15 4
53 15015934 The chitinase 3-like protein human cartilage glycoprotein 39 inhibits cellular responses to the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha. Biochem J 2004 Jun 15 2
54 15094778 Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034. Oncogene 2004 Jun 24 7
55 15115616 Binding activity of H-Ras is necessary for in vivo inhibition of ASK1 activity. Cell Res 2004 Apr 2
56 15117824 Thioredoxin-2 inhibits mitochondria-located ASK1-mediated apoptosis in a JNK-independent manner. Circ Res 2004 Jun 11 4
57 15139849 Oxidative stress inhibits MEKK1 by site-specific glutathionylation in the ATP-binding domain. Biochem J 2004 Aug 1 2
58 15210709 Direct binding of apoptosis signal-regulating kinase 1 to retinoblastoma protein: novel links between apoptotic signaling and cell cycle machinery. J Biol Chem 2004 Sep 10 1
59 15217905 Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1/JNK-dependent signaling pathway in human leukemia HL-60 cells. Carcinogenesis 2005 Jan 5
60 15218033 Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity. J Biol Chem 2004 Aug 27 2
61 15246877 S-nitrosation of thioredoxin in the nitrogen monoxide/superoxide system activates apoptosis signal-regulating kinase 1. Arch Biochem Biophys 2004 Aug 15 7
62 15310755 AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation. J Biol Chem 2004 Oct 22 1
63 15328343 Ser/Thr protein phosphatase 5 inactivates hypoxia-induced activation of an apoptosis signal-regulating kinase 1/MKK-4/JNK signaling cascade. J Biol Chem 2004 Nov 5 1
64 15592360 Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation. Cell Death Differ 2005 Jan 5
65 15598880 The ASK1-MAP kinase cascades in mammalian stress response. J Biochem 2004 Sep 2
66 15629441 CaMKII activates ASK1 and NF-kappaB to induce cardiomyocyte hypertrophy. Biochem Biophys Res Commun 2005 Feb 4 3
67 15670787 Identification of ASK1, MKK4, JNK, c-Jun, and caspase-3 as a signaling cascade involved in cadmium-induced neuronal cell apoptosis. Biochem Biophys Res Commun 2005 Mar 4 2
68 15701637 Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation. J Biol Chem 2005 Apr 15 2
69 15755722 Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor. J Biol Chem 2005 May 13 5
70 15757638 ERK1/2 are involved in low potassium-induced apoptotic signaling downstream of ASK1-p38 MAPK pathway in cultured cerebellar granule neurons. Brain Res 2005 Mar 21 2
71 15782121 Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis. Oncogene 2005 Jun 2 14
72 15824197 The antioxidant edaravone attenuates pressure overload-induced left ventricular hypertrophy. Hypertension 2005 May 1
73 15864310 ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nat Immunol 2005 Jun 1
74 15911620 Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators. J Biol Chem 2005 Jul 22 3
75 15970283 Apoptosis signal-regulating kinase 1 in leukotriene D(4)-induced activator protein-1 activation in airway smooth muscle cells. Eur J Pharmacol 2005 Jul 4 1
76 16142216 SUMO-1 represses apoptosis signal-regulating kinase 1 activation through physical interaction and not through covalent modification. EMBO Rep 2005 Oct 2
77 16195372 TNFR1- and TNFR2-mediated signaling pathways in human kidney are cell type-specific and differentially contribute to renal injury. FASEB J 2005 Oct 2
78 16278378 Signal pathway of hypoxia-inducible factor-1alpha phosphorylation and its interaction with von Hippel-Lindau tumor suppressor protein during ischemia in MiaPaCa-2 pancreatic cancer cells. Clin Cancer Res 2005 Nov 1 3
79 16337887 Differential oxidation of thioredoxin-1, thioredoxin-2, and glutathione by metal ions. Free Radic Biol Med 2006 Jan 1 5
80 16476732 Apoptosis signal-regulating kinase 1 is a direct target of E2F1 and contributes to histone deacetylase inhibitor-induced apoptosis through positive feedback regulation of E2F1 apoptotic activity. J Biol Chem 2006 Apr 14 7
81 16515547 Critical role of ASK1 in the 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells. J Neurochem 2006 Apr 9
82 16527894 A balance between Raf-1 and Fas expression sets the pace of erythroid differentiation. Blood 2006 Jul 1 1
83 16532036 Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells. Oncogene 2006 Jun 22 3
84 16644673 Impact of mitochondrial reactive oxygen species and apoptosis signal-regulating kinase 1 on insulin signaling. Diabetes 2006 May 2
85 16648474 Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. Mol Cell Biol 2006 May 1
86 16670275 Cutting edge: apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by lipopolysaccharide. J Immunol 2006 May 15 1
87 16719788 Advance in antitumor agents targeting glutathione-S-transferase. Curr Med Chem 2006 1
88 16731828 Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells. Diabetes 2006 Jun 6
89 16827794 PP2C family members play key roles in regulation of cell survival and apoptosis. Cancer Sci 2006 Jul 2
90 16945918 The marine product cephalostatin 1 activates an endoplasmic reticulum stress-specific and apoptosome-independent apoptotic signaling pathway. J Biol Chem 2006 Nov 3 1
91 16987025 The role of apoptosis signal-regulating kinase 1 in cardiomyocyte apoptosis. Antioxid Redox Signal 2006 Sep-Oct 2
92 17023263 Apoptosis signal regulating kinase-1 connects reactive oxygen species to p38 MAPK-induced mitochondrial apoptosis in UVB-irradiated human keratinocytes. Free Radic Biol Med 2006 Nov 1 13
93 17034354 Oxidative stress and growth-regulating intracellular signaling pathways in cardiac myocytes. Antioxid Redox Signal 2006 Nov-Dec 1
94 17068291 Small heat-shock protein Hsp20 attenuates beta-agonist-mediated cardiac remodeling through apoptosis signal-regulating kinase 1. Circ Res 2006 Nov 24 2
95 17081769 Thioredoxin and protein kinases in redox signaling. Semin Cancer Biol 2006 Dec 1
96 17115886 Thioredoxin and related molecules--from biology to health and disease. Antioxid Redox Signal 2007 Jan 1
97 17184177 Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complications. Antioxid Redox Signal 2007 Mar 2
98 17244475 Pathophysiological roles of ASK1-MAP kinase signaling pathways. J Biochem Mol Biol 2007 Jan 31 3
99 17251462 Pathway-specific effect of caffeine on protection against UV irradiation-induced apoptosis in corneal epithelial cells. Invest Ophthalmol Vis Sci 2007 Feb 4
100 17258890 Granzyme B induction signalling pathway in acute myeloid leukemia cell lines stimulated by tumor necrosis factor alpha and Fas ligand. Cell Signal 2007 Jun 1