Pub. Date : 2006 Jun
PMID : 16731828
6 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells. | Glucose | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens | ||
| 2 | Here, we show that high glucose induces activation of apoptosis signal-regulating kinase 1 (ASK1), an apoptosis-inducing signal that mediates endothelial cell senescence induced by hyperglycemia. | Glucose | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens | ||
| 3 | Here, we show that high glucose induces activation of apoptosis signal-regulating kinase 1 (ASK1), an apoptosis-inducing signal that mediates endothelial cell senescence induced by hyperglycemia. | Glucose | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens | ||
| 4 | High glucose induced a time-dependent increase in the levels of ASK1 expression and its activity in human umbilical vein endothelial cells (HUVECs). | Glucose | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens | ||
| 5 | However, transfection with an adenoviral construct including a dominant negative form of ASK1 gene significantly inhibited SA-beta-gal activity induced by high glucose. | 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens | ||
| 6 | However, transfection with an adenoviral construct including a dominant negative form of ASK1 gene significantly inhibited SA-beta-gal activity induced by high glucose. | Glucose | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens | ||