Title : Advance in antitumor agents targeting glutathione-S-transferase.

Pub. Date : 2006

PMID : 16719788






1 Functional Relationships(s)
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1 Glutathione-S-transferases (GSTs; EC 2.5.1.18), a family of phase II detoxification enzymes, catalyze the conjugation of glutathione with broad substrates including chemotherapeutic agents, and are involved in cell protection against apoptotic signals by inhibiting the stress-signaling cascade mediated by ASK1 (Apoptosis signal-regulating kinase)-JNK (c-Jun N-terminal kinase). Glutathione mitogen-activated protein kinase kinase kinase 5 Homo sapiens