Pub. Date : 2006 Apr
PMID : 16515547
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Critical role of ASK1 in the 6-hydroxydopamine-induced apoptosis in human neuroblastoma SH-SY5Y cells. | Oxidopamine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 2 | We observed significant activation of ASK1, p38 and JNK, as well as apoptosis in human dopaminergic neuroblastoma SH-SY5Y cells exposed to 6-OHDA. | Oxidopamine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 3 | Furthermore, suppression of the 6-OHDA-generated reactive oxygen species (ROS) by pre-incubation of cells with N-acetyl-L-cysteine effectively inhibited the 6-OHDA-induced activation of ASK1, p38 and JNK, and protected the cells from apoptosis. | Oxidopamine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 4 | Furthermore, suppression of the 6-OHDA-generated reactive oxygen species (ROS) by pre-incubation of cells with N-acetyl-L-cysteine effectively inhibited the 6-OHDA-induced activation of ASK1, p38 and JNK, and protected the cells from apoptosis. | Reactive Oxygen Species | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 5 | Furthermore, suppression of the 6-OHDA-generated reactive oxygen species (ROS) by pre-incubation of cells with N-acetyl-L-cysteine effectively inhibited the 6-OHDA-induced activation of ASK1, p38 and JNK, and protected the cells from apoptosis. | Reactive Oxygen Species | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 6 | Furthermore, suppression of the 6-OHDA-generated reactive oxygen species (ROS) by pre-incubation of cells with N-acetyl-L-cysteine effectively inhibited the 6-OHDA-induced activation of ASK1, p38 and JNK, and protected the cells from apoptosis. | Acetylcysteine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 7 | Furthermore, suppression of the 6-OHDA-generated reactive oxygen species (ROS) by pre-incubation of cells with N-acetyl-L-cysteine effectively inhibited the 6-OHDA-induced activation of ASK1, p38 and JNK, and protected the cells from apoptosis. | Oxidopamine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 8 | This study clearly shows the route from ROS generation by 6-OHDA to initiation of p38/JNK signalling via activation of ASK1 in the studied PD model. | Reactive Oxygen Species | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 9 | This study clearly shows the route from ROS generation by 6-OHDA to initiation of p38/JNK signalling via activation of ASK1 in the studied PD model. | Oxidopamine | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |