Pub. Date : 2005 May 13
PMID : 15755722
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Protein kinase D specifically mediates apoptosis signal-regulating kinase 1-JNK signaling induced by H2O2 but not tumor necrosis factor. | Hydrogen Peroxide | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 2 | Consistently, H2O2, but not TNF, induced phosphorylation of PKD and translocation of PKD from endothelial cell membrane to cytoplasm where it associates with the JNK upstream activator, apoptosis signal-regulating kinase 1 (ASK1). | Hydrogen Peroxide | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 3 | Consistently, H2O2, but not TNF, induced phosphorylation of PKD and translocation of PKD from endothelial cell membrane to cytoplasm where it associates with the JNK upstream activator, apoptosis signal-regulating kinase 1 (ASK1). | Hydrogen Peroxide | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 4 | Inhibition of PKD by Go6976 or by small interfering RNA of PKD blocked H2O2-induced ASK1-JNK activation and endothelial cell apoptosis. | Hydrogen Peroxide | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 5 | More significantly, the 14-3-3-binding defective forms of PKD failed to associate with ASK1 and to activate JNK signaling, highlighting the importance of 14-3-3 binding of PKD in H2O2-induced activation of ASK1-JNK cascade. | Hydrogen Peroxide | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |