Pub. Date : 2005 Jan
PMID : 15592360
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation. | Reactive Oxygen Species | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 2 | We have reported that apoptosis signal-regulating kinase 1 (ASK1) is required for ROS- and ER stress-induced JNK activation and apoptosis. | Reactive Oxygen Species | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 3 | We have reported that apoptosis signal-regulating kinase 1 (ASK1) is required for ROS- and ER stress-induced JNK activation and apoptosis. | Reactive Oxygen Species | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 4 | Abeta activated ASK1 mainly through production of ROS but not through ER stress in cultured neuronal cells. | Reactive Oxygen Species | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 5 | These results indicate that ROS-mediated ASK1 activation is a key mechanism for Abeta-induced neurotoxicity, which plays a central role in Alzheimer"s disease. | Reactive Oxygen Species | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |