| 1 |
33369157 | The C-terminal acidic region in the A1 domain of factor VIII facilitates thrombin-catalyzed activation and cleavage at Arg372. | 2021 Mar |
1 |
| 2 |
32327488 | Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation. | 2020 May 29 |
1 |
| 3 |
32446352 | Human platelets express functional ectonucleotidases that restrict platelet activation signaling. | 2020 Jun 18 |
1 |
| 4 |
31221752 | Rapid assembly and profiling of an anticoagulant sulfoprotein library. | 2019 Jul 9 |
2 |
| 5 |
28445805 | FAK phosphorylation plays a central role in thrombin-induced RPE cell migration. | 2017 Aug |
1 |
| 6 |
27435675 | Structural Architecture of Prothrombin in Solution Revealed by Single Molecule Spectroscopy. | 2016 Aug 26 |
1 |
| 7 |
25967238 | The focal adhesion kinase Pyk2 links Ca2+ signalling to Src family kinase activation and protein tyrosine phosphorylation in thrombin-stimulated platelets. | 2015 Jul 15 |
1 |
| 8 |
26090670 | Angiopoietin-1 Regulates Brain Endothelial Permeability through PTPN-2 Mediated Tyrosine Dephosphorylation of Occludin. | 2015 |
1 |
| 9 |
24790104 | The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth. | 2014 Jun 20 |
1 |
| 10 |
25201728 | Substantial non-electrostatic forces are needed to induce allosteric disruption of thrombin's active site through exosite 2. | 2014 Sep 26 |
1 |
| 11 |
23488775 | Therapeutic implications of endothelin and thrombin G-protein-coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors. | 2013 Apr |
1 |
| 12 |
24025335 | Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration. | 2013 Oct 25 |
1 |
| 13 |
22236469 | Synthesis and evaluation of platelet aggregation inhibitory activity of some 3-phenyl-pyrroloquinazolinones. | 2012 Feb |
1 |
| 14 |
22950787 | Sitagliptin: anti-platelet effect in diabetes and healthy volunteers. | 2012 |
1 |
| 15 |
22956765 | The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation. | 2012 Nov |
1 |
| 16 |
21388249 | Potentiation by adrenaline of agonist-induced responses in normal human platelets in vitro. | 2011 |
1 |
| 17 |
20184328 | Inhibitory properties of the P1 Tyr variant of antithrombin. | 2010 Mar 30 |
1 |
| 18 |
20600849 | Thrombin induces platelet activation in the absence of functional protease activated receptors 1 and 4 and glycoprotein Ib-IX-V. | 2010 Nov |
1 |
| 19 |
18768213 | Receptor tyrosine kinase EphA2 mediates thrombin-induced upregulation of ICAM-1 in endothelial cells in vitro. | 2009 Mar |
1 |
| 20 |
19359598 | A role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis. | 2009 May 8 |
1 |
| 21 |
19660790 | In retinal vein occlusion platelet response to thrombin is increased. | 2009 Dec |
1 |
| 22 |
19718473 | Integrin-dependent translocation of LASP-1 to the cytoskeleton of activated platelets correlates with LASP-1 phosphorylation at tyrosine 171 by Src-kinase. | 2009 Sep |
1 |
| 23 |
17904203 | Inhibition of tyrosine kinase activity prevents the adhesive and cohesive properties of platelets and the expression of procoagulant activity in response to collagen. | 2008 |
1 |
| 24 |
18362147 | Activation of Syk by protein kinase C-delta regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65. | 2008 May 23 |
3 |
| 25 |
19030108 | Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets. | 2008 |
1 |
| 26 |
17012367 | c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cells. | 2007 Feb |
2 |
| 27 |
17461933 | Effects of plasma membrane Ca(2+) -ATPase tyrosine phosphorylation on human platelet function. | 2007 May |
4 |
| 28 |
17570831 | Coincident regulation of PKCdelta in human platelets by phosphorylation of Tyr311 and Tyr565 and phospholipase C signalling. | 2007 Sep 15 |
1 |
| 29 |
17601492 | Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity. | 2007 Aug 15 |
1 |
| 30 |
17721620 | Tyrosine phosphorylation / dephosphorylation balance is involved in thrombin-evoked microtubular reorganisation in human platelets. | 2007 Aug |
2 |
| 31 |
17854313 | WASP localizes to the membrane skeleton of platelets. | 2007 Oct |
1 |
| 32 |
16148030 | Thrombin induces expression of FGF-2 via activation of PI3K-Akt-Fra-1 signaling axis leading to DNA synthesis and motility in vascular smooth muscle cells. | 2006 Jan |
1 |
| 33 |
16169188 | A new role for FcgammaRIIA in the potentiation of human platelet activation induced by weak stimulation. | 2006 Jun |
3 |
| 34 |
16527988 | Novel role for STAT-5B in the regulation of Hsp27-FGF-2 axis facilitating thrombin-induced vascular smooth muscle cell growth and motility. | 2006 Apr 14 |
1 |
| 35 |
16581796 | Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. | 2006 Apr |
1 |
| 36 |
16898954 | Platelet nitric oxide synthase is activated by tyrosine dephosphorylation: possible role for SHP-1 phosphatase. | 2006 Nov |
2 |
| 37 |
16920985 | c-Src mediates thrombin-induced NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells. | 2006 Sep 1 |
1 |
| 38 |
17001711 | Mapping the fluorophilicity of a hydrophobic pocket: synthesis and biological evaluation of tricyclic thrombin inhibitors directing fluorinated alkyl groups into the p pocket. | 2006 Nov |
1 |
| 39 |
17076509 | A minimalist approach toward protein recognition by epitope transfer from functionally evolved beta-sheet surfaces. | 2006 Nov 8 |
1 |
| 40 |
15548519 | STAT-3-dependent cytosolic phospholipase A2 expression is required for thrombin-induced vascular smooth muscle cell motility. | 2005 Jan 28 |
2 |
| 41 |
15582990 | Thrombomodulin changes the molecular surface of interaction and the rate of complex formation between thrombin and protein C. | 2005 Mar 4 |
1 |
| 42 |
15667216 | Dynamics of the fragment of thrombomodulin containing the fourth and fifth epidermal growth factor-like domains correlate with function. | 2005 Feb 1 |
3 |
| 43 |
15795233 | Thrombin-induced tyrosine phosphorylation of HS1 in human platelets is sequentially catalyzed by Syk and Lyn tyrosine kinases and associated with the cellular migration of the protein. | 2005 Jun 3 |
4 |
| 44 |
15811957 | Molecular mechanism and functional implications of thrombin-mediated tyrosine phosphorylation of PKCdelta in platelets. | 2005 Jul 15 |
4 |
| 45 |
15886804 | P2Y12 ADP receptor-dependent tyrosine phosphorylation of proteins of 27 and 31 kDa in thrombin-stimulated human platelets. | 2005 May |
4 |
| 46 |
15968387 | Deletion of the 60-loop provides new insights into the substrate and inhibitor specificity of thrombin. | 2005 Jun |
1 |
| 47 |
16001397 | Detection of the centriole tyr- or acet-tubulin changes in endothelial cells treated with thrombin using microscopic immunocytochemistry. | 2005 Sep |
2 |
| 48 |
16126727 | Endothelial thrombomodulin induces Ca2+ signals and nitric oxide synthesis through epidermal growth factor receptor kinase and calmodulin kinase II. | 2005 Oct 28 |
1 |
| 49 |
16287612 | Efficient tyrosine phosphorylation of proteins after activation of platelets with thrombin depends on intact glycoprotein Ib. | 2005 Dec |
4 |
| 50 |
14978285 | Crystal structure of the complex between thrombin and the central "E" region of fibrin. | 2004 Mar 2 |
1 |