Tyrosine

coagulation factor II, thrombin ; Homo sapiens







225 Article(s)
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1 33369157 The C-terminal acidic region in the A1 domain of factor VIII facilitates thrombin-catalyzed activation and cleavage at Arg372. 2021 Mar 1
2 32327488 Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation. 2020 May 29 1
3 32446352 Human platelets express functional ectonucleotidases that restrict platelet activation signaling. 2020 Jun 18 1
4 31221752 Rapid assembly and profiling of an anticoagulant sulfoprotein library. 2019 Jul 9 2
5 28445805 FAK phosphorylation plays a central role in thrombin-induced RPE cell migration. 2017 Aug 1
6 27435675 Structural Architecture of Prothrombin in Solution Revealed by Single Molecule Spectroscopy. 2016 Aug 26 1
7 25967238 The focal adhesion kinase Pyk2 links Ca2+ signalling to Src family kinase activation and protein tyrosine phosphorylation in thrombin-stimulated platelets. 2015 Jul 15 1
8 26090670 Angiopoietin-1 Regulates Brain Endothelial Permeability through PTPN-2 Mediated Tyrosine Dephosphorylation of Occludin. 2015 1
9 24790104 The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth. 2014 Jun 20 1
10 25201728 Substantial non-electrostatic forces are needed to induce allosteric disruption of thrombin's active site through exosite 2. 2014 Sep 26 1
11 23488775 Therapeutic implications of endothelin and thrombin G-protein-coupled receptor transactivation of tyrosine and serine/threonine kinase cell surface receptors. 2013 Apr 1
12 24025335 Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration. 2013 Oct 25 1
13 22236469 Synthesis and evaluation of platelet aggregation inhibitory activity of some 3-phenyl-pyrroloquinazolinones. 2012 Feb 1
14 22950787 Sitagliptin: anti-platelet effect in diabetes and healthy volunteers. 2012 1
15 22956765 The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of ╬▓-catenin phosphorylation. 2012 Nov 1
16 21388249 Potentiation by adrenaline of agonist-induced responses in normal human platelets in vitro. 2011 1
17 20184328 Inhibitory properties of the P1 Tyr variant of antithrombin. 2010 Mar 30 1
18 20600849 Thrombin induces platelet activation in the absence of functional protease activated receptors 1 and 4 and glycoprotein Ib-IX-V. 2010 Nov 1
19 18768213 Receptor tyrosine kinase EphA2 mediates thrombin-induced upregulation of ICAM-1 in endothelial cells in vitro. 2009 Mar 1
20 19359598 A role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis. 2009 May 8 1
21 19660790 In retinal vein occlusion platelet response to thrombin is increased. 2009 Dec 1
22 19718473 Integrin-dependent translocation of LASP-1 to the cytoskeleton of activated platelets correlates with LASP-1 phosphorylation at tyrosine 171 by Src-kinase. 2009 Sep 1
23 17904203 Inhibition of tyrosine kinase activity prevents the adhesive and cohesive properties of platelets and the expression of procoagulant activity in response to collagen. 2008 1
24 18362147 Activation of Syk by protein kinase C-delta regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65. 2008 May 23 3
25 19030108 Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets. 2008 1
26 17012367 c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cells. 2007 Feb 2
27 17461933 Effects of plasma membrane Ca(2+) -ATPase tyrosine phosphorylation on human platelet function. 2007 May 4
28 17570831 Coincident regulation of PKCdelta in human platelets by phosphorylation of Tyr311 and Tyr565 and phospholipase C signalling. 2007 Sep 15 1
29 17601492 Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity. 2007 Aug 15 1
30 17721620 Tyrosine phosphorylation / dephosphorylation balance is involved in thrombin-evoked microtubular reorganisation in human platelets. 2007 Aug 2
31 17854313 WASP localizes to the membrane skeleton of platelets. 2007 Oct 1
32 16148030 Thrombin induces expression of FGF-2 via activation of PI3K-Akt-Fra-1 signaling axis leading to DNA synthesis and motility in vascular smooth muscle cells. 2006 Jan 1
33 16169188 A new role for FcgammaRIIA in the potentiation of human platelet activation induced by weak stimulation. 2006 Jun 3
34 16527988 Novel role for STAT-5B in the regulation of Hsp27-FGF-2 axis facilitating thrombin-induced vascular smooth muscle cell growth and motility. 2006 Apr 14 1
35 16581796 Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization. 2006 Apr 1
36 16898954 Platelet nitric oxide synthase is activated by tyrosine dephosphorylation: possible role for SHP-1 phosphatase. 2006 Nov 2
37 16920985 c-Src mediates thrombin-induced NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells. 2006 Sep 1 1
38 17001711 Mapping the fluorophilicity of a hydrophobic pocket: synthesis and biological evaluation of tricyclic thrombin inhibitors directing fluorinated alkyl groups into the p pocket. 2006 Nov 1
39 17076509 A minimalist approach toward protein recognition by epitope transfer from functionally evolved beta-sheet surfaces. 2006 Nov 8 1
40 15548519 STAT-3-dependent cytosolic phospholipase A2 expression is required for thrombin-induced vascular smooth muscle cell motility. 2005 Jan 28 2
41 15582990 Thrombomodulin changes the molecular surface of interaction and the rate of complex formation between thrombin and protein C. 2005 Mar 4 1
42 15667216 Dynamics of the fragment of thrombomodulin containing the fourth and fifth epidermal growth factor-like domains correlate with function. 2005 Feb 1 3
43 15795233 Thrombin-induced tyrosine phosphorylation of HS1 in human platelets is sequentially catalyzed by Syk and Lyn tyrosine kinases and associated with the cellular migration of the protein. 2005 Jun 3 4
44 15811957 Molecular mechanism and functional implications of thrombin-mediated tyrosine phosphorylation of PKCdelta in platelets. 2005 Jul 15 4
45 15886804 P2Y12 ADP receptor-dependent tyrosine phosphorylation of proteins of 27 and 31 kDa in thrombin-stimulated human platelets. 2005 May 4
46 15968387 Deletion of the 60-loop provides new insights into the substrate and inhibitor specificity of thrombin. 2005 Jun 1
47 16001397 Detection of the centriole tyr- or acet-tubulin changes in endothelial cells treated with thrombin using microscopic immunocytochemistry. 2005 Sep 2
48 16126727 Endothelial thrombomodulin induces Ca2+ signals and nitric oxide synthesis through epidermal growth factor receptor kinase and calmodulin kinase II. 2005 Oct 28 1
49 16287612 Efficient tyrosine phosphorylation of proteins after activation of platelets with thrombin depends on intact glycoprotein Ib. 2005 Dec 4
50 14978285 Crystal structure of the complex between thrombin and the central "E" region of fibrin. 2004 Mar 2 1