Title : Efficient tyrosine phosphorylation of proteins after activation of platelets with thrombin depends on intact glycoprotein Ib.

Pub. Date : 2005 Dec

PMID : 16287612






4 Functional Relationships(s)
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1 Efficient tyrosine phosphorylation of proteins after activation of platelets with thrombin depends on intact glycoprotein Ib. Tyrosine coagulation factor II, thrombin Homo sapiens
2 Tyrosine phosphorylation in whole platelet lysates and in cytoskeletal extracts was evaluated after activation with thrombin and with the thrombin receptor-activating peptide (TRAP). Tyrosine coagulation factor II, thrombin Homo sapiens
3 After activation of control platelets with thrombin or TRAP, multiple proteins became tyrosine phosphorylated in platelet lysates and some of them associated with the cytoskeletal fraction. Tyrosine coagulation factor II, thrombin Homo sapiens
4 The signaling mechanisms occurring through tyrosine phosphorylation of proteins triggered by thrombin seem to be dependent on intact GPIb. Tyrosine coagulation factor II, thrombin Homo sapiens