Title : c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cells.

Pub. Date : 2007 Feb

PMID : 17012367






2 Functional Relationships(s)
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1 We now provide evidence that activation of c-Src is crucial in signaling thrombin-induced ICAM-1 expression via tyrosine phosphorylation of RelA/p65. Tyrosine coagulation factor II, thrombin Homo sapiens
2 We also observed that thrombin induced tyrosine phosphorylation of RelA/p65, and this phosphorylation was lost upon inhibition of c-Src, consistent with the requirement of activated c-Src for interaction with RelA/p65. Tyrosine coagulation factor II, thrombin Homo sapiens