Pub. Date : 2005 Jun 3
PMID : 15795233
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thrombin-induced tyrosine phosphorylation of HS1 in human platelets is sequentially catalyzed by Syk and Lyn tyrosine kinases and associated with the cellular migration of the protein. | Tyrosine | coagulation factor II, thrombin | Homo sapiens |
| 2 | Thrombin stimulation of platelets triggers Tyr phosphorylation of several signaling proteins, most of which remain unidentified. | Tyrosine | coagulation factor II, thrombin | Homo sapiens |
| 3 | In this study, we demonstrate for the first time that hematopoietic lineage cell-specific protein 1 (HS1) undergoes a transient Tyr phosphorylation in human platelets stimulated with thrombin. | Tyrosine | coagulation factor II, thrombin | Homo sapiens |
| 4 | All together these results indicate that HS1 Tyr phosphorylation catalyzed by Syk and Lyn plays a crucial role in the translocation of the protein to the membrane and is involved in the cytoskeleton rearrangement triggered by thrombin in human platelets. | Tyrosine | coagulation factor II, thrombin | Homo sapiens |