Title : Thrombin induces platelet activation in the absence of functional protease activated receptors 1 and 4 and glycoprotein Ib-IX-V.

Pub. Date : 2010 Nov

PMID : 20600849






1 Functional Relationships(s)
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1 In PAR1- and PAR4-desensitized platelets, thrombin also induced tyrosine phosphorylation of some substrates, but, surprisingly, this event was largely independent of GPIbalpha binding, as it persisted upon platelet treatment with mocarhagin. Tyrosine coagulation factor II, thrombin Homo sapiens