Title : Dynamics of the fragment of thrombomodulin containing the fourth and fifth epidermal growth factor-like domains correlate with function.

Pub. Date : 2005 Feb 1

PMID : 15667216






3 Functional Relationships(s)
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1 Backbone dynamics of the thrombin-binding residues Tyr 413 and Ile 414 are inversely correlated with thrombin binding. Tyrosine coagulation factor II, thrombin Homo sapiens
2 Backbone dynamics of the thrombin-binding residues Tyr 413 and Ile 414 are inversely correlated with thrombin binding. Tyrosine coagulation factor II, thrombin Homo sapiens
3 The preordering of the backbone of Tyr 413 and Ile 414 only occurs in the two-domain fragments, revealing a role for the fourth domain in thrombin binding as well as in anticoagulant cofactor activity. Tyrosine coagulation factor II, thrombin Homo sapiens