Tyrosine

coagulation factor II, thrombin ; Homo sapiens







225 Article(s)
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51 15016733 GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions. 2004 Apr 30 1
52 15313016 Sustained stimulation of platelet thrombin receptor is associated with tyrosine dephosphorylation of a novel p67 peptide in a manner regulated by extracellular calcium. 2004 Aug 23 2
53 12603843 Thrombin induces in vivo degeneration of nigral dopaminergic neurones along with the activation of microglia. 2003 Mar 1
54 12794066 Roles of low specificity and cofactor interaction sites on thrombin during factor XIII activation. Competition for cofactor sites on thrombin determines its fate. 2003 Aug 22 1
55 12846829 Glycoprotein Ib-mediated platelet activation. A signalling pathway triggered by thrombin. 2003 Jul 1
56 12847109 CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells. 2003 Sep 19 1
57 14531686 Probing the kinetic landscape of transient peptide-protein interactions by use of peptide (15)n NMR relaxation dispersion spectroscopy: binding of an antithrombin peptide to human prothrombin. 2003 Oct 15 1
58 14598382 Regulation of Na,K-ATPase function in the lens. 2003 Nov 1 1
59 11756163 Platelet endothelial cell adhesion molecule-1 signaling inhibits the activation of human platelets. 2002 Jan 1 1
60 11799111 Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase. 2002 Apr 5 1
61 11901150 Three-dimensional modeling of thrombin-fibrinogen interaction. 2002 May 24 1
62 12031920 Phosphotyrosine proteins in platelets from patients with storage pool disease: direct relation between granule defects and defective signal transduction. 2002 Jun 2
63 12057926 TRAP induces more intense tyrosine phosphorylation than thrombin with differential ultrastructural features. 2002 Jun 1
64 12112843 Identification of the phosphotyrosine proteome from thrombin activated platelets. 2002 Jun 1
65 12411320 Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C. 2002 Nov 15 1
66 12427016 Probing the hirudin-thrombin interaction by incorporation of noncoded amino acids and molecular dynamics simulation. 2002 Nov 19 1
67 11110790 Integrin-independent tyrosine phosphorylation of p125(fak) in human platelets stimulated by collagen. 2001 Feb 2 1
68 11278899 Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation. 2001 May 25 1
69 11307817 The amino acid sequence in fibrin responsible for high affinity thrombin binding. 2001 Mar 1
70 11311131 Involvement of Hic-5 in platelet activation: integrin alphaIIbbeta3-dependent tyrosine phosphorylation and association with proline-rich tyrosine kinase 2. 2001 May 1 1
71 11360180 Differential requirements for ERK1/2 and P38 MAPK activation by thrombin in T cells. Role of P59Fyn and PKCepsilon. 2001 Apr 12 1
72 11389697 Thrombopoietin stimulates cortactin translocation to the cytoskeleton independently of tyrosine phosphorylation. 2001 Jun 15 1
73 11557600 Synergistic effects of tumor necrosis factor-alpha and thrombin in increasing endothelial permeability. 2001 Oct 1
74 11594781 Involvement of tyrosine phosphatase PTP1D in the inhibition of interleukin-6-induced Stat3 signaling by alpha-thrombin. 2001 Oct 19 2
75 10642282 Tyrosine phosphorylation of human platelet plasma membrane Ca(2+)-ATPase in hypertension. 2000 Jan 1
76 10677232 Sodium binding site of factor Xa: role of sodium in the prothrombinase complex. 2000 Feb 22 1
77 10681592 SHP2 association with VE-cadherin complexes in human endothelial cells is regulated by thrombin. 2000 Feb 25 2
78 10704823 Tyrosine phosphorylation and association of FcgammaRII and p72(Syk) are not limited to the FcgammaRII signalling pathway. 2000 Mar 1
79 10739244 The crystal structures of human alpha-thrombin complexed with active site-directed diamino benzo[b]thiophene derivatives: a binding mode for a structurally novel class of inhibitors. 2000 Jan 1
80 10739383 Oxidation of human alpha-thrombin by the myeloperoxidase-H2O2-chloride system: structural and functional effects. 2000 Feb 1
81 10748008 Role of proexosite I in factor Va-dependent substrate interactions of prothrombin activation. 2000 Jun 2 2
82 10749687 Involvement of proline-rich tyrosine kinase 2 in platelet activation: tyrosine phosphorylation mostly dependent on alphaIIbbeta3 integrin and protein kinase C, translocation to the cytoskeleton and association with Shc through Grb2. 2000 Apr 15 1
83 10794720 pp60c-src associates with the SH2-containing inositol-5-phosphatase SHIP1 and is involved in its tyrosine phosphorylation downstream of alphaIIbbeta3 integrin in human platelets. 2000 May 15 1
84 10820165 Regenerative and proinflammatory effects of thrombin on human proximal tubular cells. 2000 Jun 4
85 11020444 Inhibition of cellular action of thrombin by N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3, 2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist. 2000 Nov 15 1
86 11034940 Participation of tyrosine phosphorylation in cytoskeletal reorganization, alpha(IIb)beta(3) integrin receptor activation, and aspirin-insensitive mechanisms of thrombin-stimulated human platelets. 2000 Oct 17 2
87 11042121 Platelet alpha IIb-beta 3 integrin engagement induces the tyrosine phosphorylation of Cbl and its association with phosphoinositide 3-kinase and Syk. 2000 Nov 1 1
88 11092463 Defective platelet aggregation in polycythaemia vera is not caused by impaired calcium signaling, phospholipase D activation or decreased amounts of focal adhesion proteins. 2000 Nov 1
89 9928954 Phosphoinositide 3-kinase and integrin signalling are involved in activation of Bruton tyrosine kinase in thrombin-stimulated platelets. 1999 Jan 22 1
90 10026222 Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets. 1999 Feb 26 1
91 10051558 Unexpected crucial role of residue 225 in serine proteases. 1999 Mar 2 1
92 10080949 alpha-thrombin inhibits interleukin-6-induced Stat3 signaling and gp130 gene expression in primary cultures of human lung fibroblasts. 1999 Mar 24 1
93 10091587 Role of autocrine stimulation on the effects of cyclic AMP on protein and lipid phosphorylation in collagen-activated and thrombin-activated platelets. 1999 Feb 1
94 10093970 Suppression of protein kinase C is associated with inhibition of PYK2 tyrosine phosphorylation and enhancement of PYK2 interaction with Src in thrombin-activated platelets. 1999 Mar 15 1
95 10464282 Thrombin interacts with thrombomodulin, protein C, and thrombin-activatable fibrinolysis inhibitor via specific and distinct domains. 1999 Sep 3 1
96 10508911 Thrombin-induced association of SHP-2 with multiple tyrosine-phosphorylated proteins in human platelets. 1999 Oct 1 1
97 10598576 Pertussis toxin-sensitive and -insensitive thrombin stimulation of Shc phosphorylation and mitogenesis are mediated through distinct pathways. 1999 Dec 2
98 12774450 Thrombin contraction of vascular smooth muscle: implications for vasospasm. 1999 1
99 16801121 Role of tyrosine phosphorylation in regulation of inositol 1,4,5-trisphosphate-mediated Ca2+ release in human platelets. 1999 2
100 9459347 Thrombopoietin activates human platelets and induces tyrosine phosphorylation of p80/85 cortactin. 1998 Jan 1