Tyrosine

protein tyrosine kinase 2 beta ; Homo sapiens







215 Article(s)
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1 33277387 A PKCβ-LYN-PYK2 Signaling Axis Is Critical for MCP-1-Dependent Migration and Adhesion of Monocytes. 2021 Jan 1 1
2 34944965 SHED-Dependent Oncogenic Signaling of the PEAK3 Pseudo-Kinase. 2021 Dec 17 1
3 31755225 Novel Pyrimidines as Multitarget Protein Tyrosine Kinase Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis (IPF). 2020 Jan 17 1
4 32510326 CD56 regulates human NK cell cytotoxicity through Pyk2. 2020 Jun 8 1
5 32727877 Pyk2 Regulates Human Papillomavirus Replication by Tyrosine Phosphorylation of the E2 Protein. 2020 Sep 29 3
6 33080786 Calmodulin Directly Interacts with the Cx43 Carboxyl-Terminus and Cytoplasmic Loop Containing Three ODDD-Linked Mutants (M147T, R148Q, and T154A) that Retain α-Helical Structure, but Exhibit Loss-of-Function and Cellular Trafficking Defects. 2020 Oct 17 1
7 31671564 Secondary Somatic Mutations in G-Protein-Related Pathways and Mutation Signatures in Uveal Melanoma. 2019 Oct 30 1
8 29133485 Pyk2 and FAK differentially regulate invadopodia formation and function in breast cancer cells. 2018 Jan 2 1
9 29438996 Global Identification of Small Ubiquitin-related Modifier (SUMO) Substrates Reveals Crosstalk between SUMOylation and Phosphorylation Promotes Cell Migration. 2018 May 2
10 30250159 PYK2 negatively regulates the Hippo pathway in TNBC by stabilizing TAZ protein. 2018 Sep 24 1
11 28385807 Pyk2 phosphorylation of VE-PTP downstream of STIM1-induced Ca2+ entry regulates disassembly of adherens junctions. 2017 Jun 1 2
12 28818394 Focal adhesion kinase family is involved in matrix contraction by transdifferentiated Müller cells. 2017 Nov 3
13 26645934 Potential sites of CFTR activation by tyrosine kinases. 2016 1
14 26702053 Insulin Receptor Substrate 1, the Hub Linking Follicle-stimulating Hormone to Phosphatidylinositol 3-Kinase Activation. 2016 Feb 26 1
15 26743491 Osteoprotegerin disrupts peripheral adhesive structures of osteoclasts by modulating Pyk2 and Src activities. 2016 May 3 2
16 27271350 Supramolecular protection from the enzymatic tyrosine phosphorylation in a polypeptide. 2016 Jun 21 1
17 24981431 The upregulation of NR2A-containing N-methyl-D-aspartate receptor function by tyrosine phosphorylation of postsynaptic density 95 via facilitating Src/proline-rich tyrosine kinase 2 activation. 2015 Apr 3
18 25708150 OGD induced modification of FAK- and PYK2-coupled pathways in organotypic hippocampal slice cultures. 2015 May 5 8
19 25713079 A role for the tyrosine kinase Pyk2 in depolarization-induced contraction of vascular smooth muscle. 2015 Apr 3 1
20 24800979 Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter. 2014 Aug 20 2
21 24965120 HIV-1 Tat C phosphorylates VE-cadherin complex and increases human brain microvascular endothelial cell permeability. 2014 Jun 26 1
22 25143406 Two Dictyostelium tyrosine kinase-like kinases function in parallel, stress-induced STAT activation pathways. 2014 Oct 15 1
23 25180269 Evidence for the involvement of proline-rich tyrosine kinase 2 in tyrosine phosphorylation downstream of protein kinase A activation during human sperm capacitation. 2014 Nov 2
24 23454381 Alpha1-adrenenoceptor stimulation inhibits cardiac excitation-contraction coupling through tyrosine phosphorylation of beta1-adrenoceptor. 2013 Apr 5 1
25 24025335 Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration. 2013 Oct 25 1
26 22382333 Effects of halogenation on tyrosine phosphorylation and peptide binding to the SRC homology 2 domain of lymphocyte-specific protein tyrosine kinase. 2012 3
27 22387535 Double-edged sword effect of biochanin to inhibit nuclear factor kappaB: suppression of serine/threonine and tyrosine kinases. 2012 May 15 1
28 22581261 DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. 2012 May 13 1
29 22581436 PYK-2 is tyrosine phosphorylated after activation of pituitary adenylate cyclase activating polypeptide receptors in lung cancer cells. 2012 Nov 5
30 22699506 Identification of the kinase that activates a nonmetazoan STAT gives insights into the evolution of phosphotyrosine-SH2 domain signaling. 2012 Jul 10 1
31 22923218 Chemokine receptor 7 via proline-rich tyrosine kinase-2 upregulates the chemotaxis and migration ability of squamous cell carcinoma of the head and neck. 2012 Nov 2
32 23131831 Novel Phosphorylations of IKKγ/NEMO. 2012 Nov 6 1
33 20849950 The Pyk2 FERM regulates Pyk2 complex formation and phosphorylation. 2011 Jan 1
34 21238585 CD44-mediated elongated T cell spreading requires Pyk2 activation by Src family kinases, extracellular calcium, phospholipase C and phosphatidylinositol-3 kinase. 2011 May 1
35 21357692 Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia. 2011 Apr 22 2
36 21531776 Thrombospondin-1 opens the paracellular pathway in pulmonary microvascular endothelia through EGFR/ErbB2 activation. 2011 Jul 1
37 21820892 Label-free electrochemical measurement of protein tyrosine kinase activity and inhibition based on electro-catalyzed tyrosine signaling. 2011 Oct 15 1
38 19857473 Chemokine-like factor 1, a novel cytokine, induces nerve cell migration through the non-extracellular Ca2+-dependent tyrosine kinases pathway. 2010 Jan 13 1
39 19861182 Effects of micrometric titanium particles on osteoblast attachment and cytoskeleton architecture. 2010 Apr 1
40 20028775 The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems. 2010 Apr 4
41 20074345 Cell aggregation induces phosphorylation of PECAM-1 and Pyk2 and promotes tumor cell anchorage-independent growth. 2010 Jan 14 1
42 20303997 Genistein directly inhibits native and recombinant NMDA receptors. 2010 Jun 1
43 20381867 T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells. 2010 May 1
44 20507587 Hematopoietic Pyk2 regulates migration of differentiated HL-60 cells. 2010 May 27 2
45 20543098 Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2. 2010 Jul 15 3
46 20688918 Regulation of the tyrosine kinase Pyk2 by calcium is through production of reactive oxygen species in cytotoxic T lymphocytes. 2010 Oct 8 1
47 21429240 HCMV pUS28 initiates pro-migratory signaling via activation of Pyk2 kinase. 2010 Dec 7 2
48 22137642 Regulation and differential role of the tissue factor isoforms in cardiovascular biology. 2010 Aug 1
49 18954908 LPS-induced MCP-1 expression in human microvascular endothelial cells is mediated by the tyrosine kinase, Pyk2 via the p38 MAPK/NF-kappaB-dependent pathway. 2009 Feb 1
50 19207108 A Pyk2-Vav1 complex is recruited to beta3-adhesion sites to initiate Rho activation. 2009 Apr 28 1