Title : DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation.

Pub. Date : 2012 May 13

PMID : 22581261






1 Functional Relationships(s)
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Compound Name
Protein Name
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1 After ligation of TLR9, DOCK8 became tyrosine-phosphorylated by Pyk2, bound the Src-family kinase Lyn and linked TLR9 to a Src-kinase Syk-transcription factor STAT3 cascade essential for TLR9-driven B cell proliferation and differentiation. Tyrosine protein tyrosine kinase 2 beta Homo sapiens