Title : Pyk2 and FAK differentially regulate invadopodia formation and function in breast cancer cells.

Pub. Date : 2018 Jan 2

PMID : 29133485

1 Functional Relationships(s)
Compound Name
Protein Name
1 Pyk2 colocalizes with cortactin to invadopodia of invasive breast cancer cells, where it mediates epidermal growth factor-induced cortactin tyrosine phosphorylation both directly and indirectly via Src-mediated Abl-related gene (Arg) activation, leading to actin polymerization in invadopodia, extracellular matrix degradation, and tumor cell invasion. Tyrosine protein tyrosine kinase 2 beta Homo sapiens