Title : LPS-induced MCP-1 expression in human microvascular endothelial cells is mediated by the tyrosine kinase, Pyk2 via the p38 MAPK/NF-kappaB-dependent pathway.

Pub. Date : 2009 Feb

PMID : 18954908

1 Functional Relationships(s)
Compound Name
Protein Name
1 Inhibition of Pyk2 activity using a pharmacological inhibitor, Tyrphostin A9 significantly attenuated LPS-induced Pyk2 tyrosine phosphorylation, p38 MAP kinase (MAPK) activation, NF-kappaB activation, and MCP-1 expression. Tyrosine protein tyrosine kinase 2 beta Homo sapiens