Pub. Date : 2010 Apr
PMID : 20028775
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems. | Tyrosine | protein tyrosine kinase 2 beta | Homo sapiens |
| 2 | To address this issue, the role of individual signaling pathways in the phosphorylation of Pyk2 tyrosines 402 and 580 upon TCR activation was assessed in human T cells. | Tyrosine | protein tyrosine kinase 2 beta | Homo sapiens |
| 3 | In contrast to other receptor systems, the TCR-induced phosphorylation of Pyk2 tyrosines 402 and 580 was dependent on the Src family kinases, Fyn or Lck. | Tyrosine | protein tyrosine kinase 2 beta | Homo sapiens |
| 4 | Interestingly, the TCR-mediated phosphorylation of Pyk2 tyrosines 402 and 580 did not require Ca(2+) influx, ZAP-70 activation, actin cytoskeleton rearrangement, or PI3K function. | Tyrosine | protein tyrosine kinase 2 beta | Homo sapiens |