Title : The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems.

Pub. Date : 2010 Apr

PMID : 20028775






4 Functional Relationships(s)
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1 The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems. Tyrosine protein tyrosine kinase 2 beta Homo sapiens
2 To address this issue, the role of individual signaling pathways in the phosphorylation of Pyk2 tyrosines 402 and 580 upon TCR activation was assessed in human T cells. Tyrosine protein tyrosine kinase 2 beta Homo sapiens
3 In contrast to other receptor systems, the TCR-induced phosphorylation of Pyk2 tyrosines 402 and 580 was dependent on the Src family kinases, Fyn or Lck. Tyrosine protein tyrosine kinase 2 beta Homo sapiens
4 Interestingly, the TCR-mediated phosphorylation of Pyk2 tyrosines 402 and 580 did not require Ca(2+) influx, ZAP-70 activation, actin cytoskeleton rearrangement, or PI3K function. Tyrosine protein tyrosine kinase 2 beta Homo sapiens