Title : Evidence for the involvement of proline-rich tyrosine kinase 2 in tyrosine phosphorylation downstream of protein kinase A activation during human sperm capacitation.

Pub. Date : 2014 Nov

PMID : 25180269






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Experiments aimed to identify the kinase responsible for these observations revealed the presence of proline-rich tyrosine kinase 2 (PYK2), a focal adhesion kinase (FAK) family member, in human sperm, and the use of PF431396, an FAK inhibitor, supported the involvement of PYK2 in Tyr phosphorylation downstream of PKA activation. Tyrosine protein tyrosine kinase 2 beta Homo sapiens
2 Together, our observations support PYK2 as an intermediary component of Ca(2+) signaling between PKA-mediated and Tyr phosphorylations that is required for achieving functional human sperm capacitation. Tyrosine protein tyrosine kinase 2 beta Homo sapiens