Title : Pyk2 phosphorylation of VE-PTP downstream of STIM1-induced Ca2+ entry regulates disassembly of adherens junctions.

Pub. Date : 2017 Jun 1

PMID : 28385807






2 Functional Relationships(s)
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1 Pyk2-induced tyrosine phosphorylation of VE-PTP promoted Src binding to VE-PTP, Src activation, and subsequent VE-cadherin phosphorylation and thereby increased the endothelial permeability response. Tyrosine protein tyrosine kinase 2 beta Homo sapiens
2 Thus Pyk2 activation secondary to STIM1-induced SOCE causes tyrosine phosphorylation of VE-PTP, and VE-PTP, in turn, binds to and activates Src, thereby phosphorylating VE-cadherin to increase endothelial permeability through disassembly of AJs. Tyrosine protein tyrosine kinase 2 beta Homo sapiens