Title : Insulin Receptor Substrate 1, the Hub Linking Follicle-stimulating Hormone to Phosphatidylinositol 3-Kinase Activation.

Pub. Date : 2016 Feb 26

PMID : 26702053

1 Functional Relationships(s)
Compound Name
Protein Name
1 Treatment with FSH and increasing concentrations of exogenous IGF-1 triggers synergistic IRS1 tyrosine phosphorylation at PI3K-activating residues that persists downstream through protein kinase B (AKT) and FOXO1 (forkhead box protein O1) to drive synergistic expression of genes that underlies follicle maturation. Tyrosine protein tyrosine kinase 2 beta Homo sapiens