Title : Determination of a quantitative relationship between hepatic CYP3A5*1/*3 and CYP3A4 expression for use in the prediction of metabolic clearance in virtual populations.

Pub. Date : 2010 Nov

PMID : 21104927






2 Functional Relationships(s)
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1 Simulations indicated that for a compound with greater metabolism by CYP3A5 than CYP3A4, such as tacrolimus, incorporation of the correlation between CYP3A4 and CYP3A5 does have an impact on the prediction of oral clearance. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Simulations indicated that for a compound with greater metabolism by CYP3A5 than CYP3A4, such as tacrolimus, incorporation of the correlation between CYP3A4 and CYP3A5 does have an impact on the prediction of oral clearance. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens