Title : Tacrolimus nephrotoxicity: beware of the association of diarrhea, drug interaction and pharmacogenetics.

Pub. Date : 2010 May

PMID : 20091056






1 Functional Relationships(s)
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1 It also highlights the key role in tacrolimus pharmacokinetics of the CYP3A system and P-gp polymorphisms, and their influence in high-risk situations when enzyme activity is already affected by enterocyte damage due to diarrhoea and CCB competition. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens