Title : Mechanistic understanding of the different effects of Wuzhi Tablet (Schisandra sphenanthera extract) on the absorption and first-pass intestinal and hepatic metabolism of Tacrolimus (FK506).

Pub. Date : 2010 Apr 15

PMID : 20097278






2 Functional Relationships(s)
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1 Furthermore, 100 microM of WZ extract almost completely inhibited FK506 metabolism in rat and human liver microsomes, indicating WZ extract potently inhibited the CYP3A-mediated metabolism of FK506. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 In conclusion, WZ inhibited P-gp-mediated efflux and CYP3A-mediated metabolism of FK506, and the reduction of intestinal first-pass effect by WZ was the major cause of the increased FK506 oral bioavailability. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens