| 1 |
34920124 | AMP-activated protein kinase re-sensitizes A549 to paclitaxel via up-regulating solute carrier organic anion transporter family member 1B3 expression. | 2022 Mar |
1 |
| 2 |
35281267 | Metformin Combining PD-1 Inhibitor Enhanced Anti-Tumor Efficacy in STK11 Mutant Lung Cancer Through AXIN-1-Dependent Inhibition of STING Ubiquitination. | 2022 |
3 |
| 3 |
33887464 | LKB1 Down-Modulation by miR-17 Identifies Patients With NSCLC Having Worse Prognosis Eligible for Energy-Stress-Based Treatments. | 2021 Aug |
1 |
| 4 |
34607979 | Knockdown of LKB1 Sensitizes Endometrial Cancer Cells via AMPK Activation. | 2021 Nov 1 |
2 |
| 5 |
34927008 | Metformin for Cardiovascular Protection, Inflammatory Bowel Disease, Osteoporosis, Periodontitis, Polycystic Ovarian Syndrome, Neurodegeneration, Cancer, Inflammation and Senescence: What Is Next? | 2021 Dec 10 |
1 |
| 6 |
32934724 | Therapeutic effect of metformin in the treatment of endometrial cancer. | 2020 Nov |
1 |
| 7 |
30483811 | Molecular mechanism of LKB1 in the invasion and metastasis of colorectal cancer. | 2019 Feb |
1 |
| 8 |
30552782 | Sirtuin 4 Depletion Promotes Hepatocellular Carcinoma Tumorigenesis Through Regulating Adenosine-Monophosphate-Activated Protein Kinase Alpha/Mammalian Target of Rapamycin Axis in Mice. | 2019 Apr |
1 |
| 9 |
30710424 | Metformin and tenovin-6 synergistically induces apoptosis through LKB1-independent SIRT1 down-regulation in non-small cell lung cancer cells. | 2019 Apr |
5 |
| 10 |
31114366 | The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances. | 2019 |
2 |
| 11 |
31497348 | LKB1 deficiency promotes proliferation and invasion of glioblastoma through activation of mTOR and focal adhesion kinase signaling pathways. | 2019 |
1 |
| 12 |
28494141 | Metformin induces osteoblastic differentiation of human induced pluripotent stem cell-derived mesenchymal stem cells. | 2018 Feb |
2 |
| 13 |
29601127 | LKB1 obliterates Snail stability and inhibits pancreatic cancer metastasis in response to metformin treatment. | 2018 May |
4 |
| 14 |
29966520 | Efficacy of metformin in combination with immune checkpoint inhibitors (anti-PD-1/anti-CTLA-4) in metastatic malignant melanoma. | 2018 Jul 2 |
1 |
| 15 |
30149143 | Metformin Enhances Cisplatin-Induced Apoptosis and Prevents Resistance to Cisplatin in Co-mutated KRAS/LKB1 NSCLC. | 2018 Nov |
4 |
| 16 |
28761738 | Results of the safety run-in part of the METAL (METformin in Advanced Lung cancer) study: a multicentre, open-label phase I-II study of metformin with erlotinib in second-line therapy of patients with stage IV non-small-cell lung cancer. | 2017 |
1 |
| 17 |
28775741 | STK11 rs2075604 Polymorphism Is Associated with Metformin Efficacy in Chinese Type 2 Diabetes Mellitus. | 2017 |
4 |
| 18 |
26673006 | Metformin increases antitumor activity of MEK inhibitors through GLI1 downregulation in LKB1 positive human NSCLC cancer cells. | 2016 Jan 26 |
4 |
| 19 |
26717043 | Negative regulation of Bmi-1 by AMPK and implication in cancer progression. | 2016 Feb 2 |
1 |
| 20 |
26740120 | Metformin and pancreatic cancer: Is there a role? | 2016 Feb |
1 |
| 21 |
26745759 | LKB1 acts as a critical gatekeeper of ovarian primordial follicle pool. | 2016 Feb 2 |
2 |
| 22 |
26847819 | Metformin inhibits growth of human non-small cell lung cancer cells via liver kinase B-1-independent activation of adenosine monophosphate-activated protein kinase. | 2016 Mar |
6 |
| 23 |
26893732 | Metformin: A candidate for the treatment of gynecological tumors based on drug repositioning. | 2016 Feb |
1 |
| 24 |
24862830 | Is it time to test biguanide metformin in the treatment of melanoma? | 2015 Jan |
1 |
| 25 |
25538235 | Metformin activates AMP-activated protein kinase by promoting formation of the αβγ heterotrimeric complex. | 2015 Feb 6 |
1 |
| 26 |
25607951 | Metformin: a modulator of bevacizumab activity in cancer? A case report. | 2015 |
1 |
| 27 |
25734181 | Drug repositioning for gynecologic tumors: a new therapeutic strategy for cancer. | 2015 |
1 |
| 28 |
26383681 | Metformin: A Novel Biological Modifier of Tumor Response to Radiation Therapy. | 2015 Oct 1 |
1 |
| 29 |
26424816 | AMPK Inhibits the Stimulatory Effects of TGF-β on Smad2/3 Activity, Cell Migration, and Epithelial-to-Mesenchymal Transition. | 2015 Dec |
4 |
| 30 |
24504677 | Repositioning metformin in cancer: genetics, drug targets, and new ways of delivery. | 2014 Jun |
1 |
| 31 |
24750786 | Glioblastoma stem cells: a new target for metformin and arsenic trioxide. | 2014 Jan-Mar |
1 |
| 32 |
24916949 | AMP-activated protein kinase is required for cell survival and growth in HeLa-S3 cells in vivo. | 2014 Jun |
2 |
| 33 |
25329671 | Anti-diabetic drug metformin: challenges and perspectives for cancer therapy. | 2014 |
1 |
| 34 |
22773548 | Metformin decreases hepatocellular carcinoma risk in a dose-dependent manner: population-based and in vitro studies. | 2013 Apr |
1 |
| 35 |
23526220 | Metformin enhances cisplatin cytotoxicity by suppressing signal transducer and activator of transcription-3 activity independently of the liver kinase B1-AMP-activated protein kinase pathway. | 2013 Aug |
3 |
| 36 |
23577667 | LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription. | 2013 Apr 11 |
1 |
| 37 |
23612973 | Phosphorylation of serine 399 in LKB1 protein short form by protein kinase Cζ is required for its nucleocytoplasmic transport and consequent AMP-activated protein kinase (AMPK) activation. | 2013 Jun 7 |
3 |
| 38 |
23695170 | Synergistic effects of metformin treatment in combination with gefitinib, a selective EGFR tyrosine kinase inhibitor, in LKB1 wild-type NSCLC cell lines. | 2013 Jul 1 |
3 |
| 39 |
23991948 | LKB1/AMPK/mTOR signaling pathway in non-small-cell lung cancer. | 2013 |
2 |
| 40 |
24473757 | Metformin synergistically enhances antiproliferative effects of cisplatin and etoposide in NCI-H460 human lung cancer cells. | 2013 Nov-Dec |
1 |
| 41 |
21301998 | Metformin and cancer: new applications for an old drug. | 2012 Jun |
1 |
| 42 |
21968881 | AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications. | 2012 Jan |
2 |
| 43 |
22686561 | Targeting the liver kinase B1/AMP-activated protein kinase pathway as a therapeutic strategy for hematological malignancies. | 2012 Jul |
2 |
| 44 |
22735790 | Metformin impairs the growth of liver kinase B1-intact cervical cancer cells. | 2012 Oct |
10 |
| 45 |
23029387 | Lovastatin induces multiple stress pathways including LKB1/AMPK activation that regulate its cytotoxic effects in squamous cell carcinoma cells. | 2012 |
2 |
| 46 |
21123367 | AMPK/TSC2/mTOR-signaling intermediates are not necessary for LKB1-mediated nuclear retention of PTEN tumor suppressor. | 2011 Feb |
3 |
| 47 |
21349801 | Metformin: its emerging role in oncology. | 2011 Jan-Mar |
2 |
| 48 |
21572254 | LKB1/AMPK/mTOR signaling pathway in hematological malignancies: from metabolism to cancer cell biology. | 2011 Jul 1 |
3 |
| 49 |
21631893 | Metformin as an antitumor agent in cancer prevention and treatment. | 2011 Dec |
2 |
| 50 |
21835890 | APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathway. | 2011 Oct |
1 |