Title : Metformin activates AMP-activated protein kinase by promoting formation of the αβγ heterotrimeric complex.

Pub. Date : 2015 Feb 6

PMID : 25538235






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1 In the current study, we find that low concentrations of metformin promote the formation of the AMPK alphabetagamma complex, resulting in an increase in net phosphorylation of the AMPK alpha catalytic subunit at Thr-172 by augmenting phosphorylation by LKB1 and antagonizing dephosphorylation by PP2C. Metformin serine/threonine kinase 11 Homo sapiens