Pub. Date : 2019 Apr
PMID : 30710424
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin and tenovin-6 synergistically induces apoptosis through LKB1-independent SIRT1 down-regulation in non-small cell lung cancer cells. | Metformin | serine/threonine kinase 11 | Homo sapiens |
| 2 | Metformin in combination with tenovin-6 was found to be more effective in inhibiting cell growth than either agent alone in NSCLC cell lines with different liver kinase B1 (LKB1) status. | Metformin | serine/threonine kinase 11 | Homo sapiens |
| 3 | Metformin in combination with tenovin-6 was found to be more effective in inhibiting cell growth than either agent alone in NSCLC cell lines with different liver kinase B1 (LKB1) status. | Metformin | serine/threonine kinase 11 | Homo sapiens |
| 4 | The marked reduction in SIRT1 expression by combination of metformin and tenovin-6 increased acetylation of p53 at lysine 382 and enhanced p53 stability in LKB1-deficient A549 cells. | Metformin | serine/threonine kinase 11 | Homo sapiens |
| 5 | The study concluded that metformin with tenovin-6 may enhance antitumour effects through LKB1-independent SIRT1 down-regulation in NSCLC cells. | Metformin | serine/threonine kinase 11 | Homo sapiens |