Title : Phosphorylation of serine 399 in LKB1 protein short form by protein kinase Cζ is required for its nucleocytoplasmic transport and consequent AMP-activated protein kinase (AMPK) activation.

Pub. Date : 2013 Jun 7

PMID : 23612973






3 Functional Relationships(s)
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1 In a previous study, we demonstrated that phosphorylation of Ser-428/431 (in LKB1(L)) by protein kinase Czeta (PKCzeta) was essential for LKB1-mediated activation of AMP-activated protein kinase (AMPK) in response to oxidants or metformin. Metformin serine/threonine kinase 11 Homo sapiens
2 In a previous study, we demonstrated that phosphorylation of Ser-428/431 (in LKB1(L)) by protein kinase Czeta (PKCzeta) was essential for LKB1-mediated activation of AMP-activated protein kinase (AMPK) in response to oxidants or metformin. Metformin serine/threonine kinase 11 Homo sapiens
3 PKCzeta-dependent phosphorylation of Ser-399 triggered nucleocytoplasmic translocation of LKB1(S) in response to metformin or peroxynitrite treatment. Metformin serine/threonine kinase 11 Homo sapiens