Title : Synergistic effects of metformin treatment in combination with gefitinib, a selective EGFR tyrosine kinase inhibitor, in LKB1 wild-type NSCLC cell lines.

Pub. Date : 2013 Jul 1

PMID : 23695170






3 Functional Relationships(s)
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1 Synergistic effects of metformin treatment in combination with gefitinib, a selective EGFR tyrosine kinase inhibitor, in LKB1 wild-type NSCLC cell lines. Metformin serine/threonine kinase 11 Homo sapiens
2 RESULTS: The combination of metformin with gefitinib induced a strong antiproliferative and proapoptotic effect in NSCLC cell lines that harbored wild-type LKB1 gene. Metformin serine/threonine kinase 11 Homo sapiens
3 CONCLUSIONS: Metformin and gefitinib are synergistic in LKB1 wild-type NSCLC cells. Metformin serine/threonine kinase 11 Homo sapiens