Pub. Date : 2015 Dec
PMID : 26424816
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AMP-activated protein kinase (AMPK), an important downstream effector of the tumor suppressor liver kinase 1 (LKB1) and pharmacologic target of metformin, is well known to exert a preventive and inhibitory effect on tumorigenesis; however, its role in cancer progression and metastasis has not been well characterized. | Metformin | serine/threonine kinase 11 | Homo sapiens |
| 2 | The effect of metformin is dependent on the presence of LKB1. | Metformin | serine/threonine kinase 11 | Homo sapiens |
| 3 | As a consequence, expression of genes downstream of Smad2/3, including plasminogen activator inhibitor-1, fibronectin, and connective tissue growth factor, was suppressed by metformin in a LKB1-dependent fashion. | Metformin | serine/threonine kinase 11 | Homo sapiens |
| 4 | In addition, metformin blocked TGF-beta-induced inteleukin-6 expression through both LKB1-dependent and -independent mechanisms. | Metformin | serine/threonine kinase 11 | Homo sapiens |