Title : Maternal Metformin Treatment during Gestation and Lactation Improves Skeletal Muscle Development in Offspring of Rat Dams Fed High-Fat Diet.

Pub. Date : 2021 Sep 28

PMID : 34684418






2 Functional Relationships(s)
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1 Maternal metformin increased AMPK phosphorylation and decreased 4E-BP1 phosphorylation in SM of male and female offspring. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
2 Our data demonstrate that maternal metformin during gestation and lactation can potentially overcome the negative effects of perinatal exposure to HF diet in offspring, by altering their myogenesis, mitochondrial biogenesis and dynamics through AMPK/mTOR pathways in SM. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus