Metformin

protein kinase AMP-activated catalytic subunit alpha 2 ; Rattus norvegicus







160 Article(s)
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51 32800550 Metformin, resveratrol, and exendin-4 inhibit high phosphate-induced vascular calcification via AMPK-RANKL signaling. 2020 Sep 17 4
52 32897197 [Metformin inhibits collagen production in rat biliary fibroblasts: the molecular signaling mechanism]. 2020 May 30 3
53 32903813 Eye Drops of Metformin Prevents Fibrosis After Glaucoma Filtration Surgery in Rats via Activating AMPK/Nrf2 Signaling Pathway. 2020 2
54 32959498 Decreased AMP-activated protein kinase (AMPK) function and protective effect of metformin in neonatal rat pups exposed to hyperoxia lung injury. 2020 Sep 4
55 33093887 Metformin prevents the development of monocrotaline-induced pulmonary hypertension by decreasing serum levels of big endothelin-1. 2020 Dec 1
56 33174032 Metformin protects high glucose‑cultured cardiomyocytes from oxidative stress by promoting NDUFA13 expression and mitochondrial biogenesis via the AMPK signaling pathway. 2020 Dec 9
57 33232283 Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK/NLRP3 inflammasome pathway. 2020 Nov 24 4
58 30290168 Metformin attenuates cardiovascular and renal injury in uninephrectomized rats on DOCA-salt: Involvement of AMPK and miRNAs in cardioprotection. 2019 Jan 1 2
59 30318707 Metformin produces anxiolytic-like effects in rats by facilitating GABAA receptor trafficking to membrane. 2019 Jan 3
60 30427219 Role of PKC and AMPK in hypertonicity-stimulated water reabsorption in rat inner medullary collecting ducts. 2019 Feb 1 3
61 30445633 Metformin suppresses the esophageal carcinogenesis in rats treated with NMBzA through inhibiting AMPK/mTOR signaling pathway. 2019 Jul 4 2
62 30784077 Metformin protects PC12 cells and hippocampal neurons from H2 O 2 -induced oxidative damage through activation of AMPK pathway. 2019 Feb 19 6
63 30924377 Anticancer effect of metformin against 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine-induced rat mammary carcinogenesis is through AMPK pathway and modulation of oxidative stress markers. 2019 Jun 4
64 31085922 Metformin Prevents Progression of Experimental Pulmonary Hypertension via Inhibition of Autophagy and Activation of Adenosine Monophosphate-Activated Protein Kinase. 2019 1
65 31118410 AMPK alleviates high uric acid-induced Na+-K+-ATPase signaling impairment and cell injury in renal tubules. 2019 May 22 1
66 31132357 Alendronate-induced gastric damage in normoglycemic and hyperglycemic rats is reversed by metformin. 2019 Aug 5 2
67 31369842 Inhibition of neointima hyperplasia by the combined therapy of linagliptin and metformin via AMPK/Nox4 signaling in diabetic rats. 2019 Nov 1 3
68 31437793 Metformin attenuates autoimmune disease of the neuromotor system in animal models of myasthenia gravis. 2019 Oct 3
69 31781324 Metformin Activates the Protective Effects of the AMPK Pathway in Acute Lung Injury Caused by Paraquat Poisoning. 2019 6
70 28142230 Compound K attenuates glucose intolerance and hepatic steatosis through AMPK-dependent pathways in type 2 diabetic OLETF rats. 2018 Mar 2
71 29032153 Metformin overcomes high glucose-induced insulin resistance of podocytes by pleiotropic effects on SIRT1 and AMPK. 2018 Jan 7
72 29393487 Effects of metformin on the expression of AMPK and STAT3 in the spinal dorsal horn of rats with neuropathic pain. 2018 Apr 4
73 29526538 Activation of AMPK inhibits inflammatory response during hypoxia and reoxygenation through modulating JNK-mediated NF-κB pathway. 2018 Jun 1
74 29579593 AMP-activated protein kinase protects against necroptosis via regulation of Keap1-PGAM5 complex. 2018 May 15 3
75 29656591 AMP-activated protein kinase-dependent induction of autophagy by erythropoietin protects against spinal cord injury in rats. 2018 Dec 1
76 29670844 The Eeffect of Metformin Combined with Calcium-Vitamin D3 Against Diet-Induced Nonalcoholic Fatty Liver Disease. 2018 Mar 2
77 29753686 Pharmacological inhibition of the mitochondrial NADPH oxidase 4/PKCα/Gal-3 pathway reduces left ventricular fibrosis following myocardial infarction. 2018 Sep 4
78 29895585 Metformin Improves Neurologic Outcome Via AMP-Activated Protein Kinase-Mediated Autophagy Activation in a Rat Model of Cardiac Arrest and Resuscitation. 2018 Jun 12 5
79 29958542 Effect of resveratrol and metformin on ovarian reserve and ultrastructure in PCOS: an experimental study. 2018 Jun 29 3
80 29976587 Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin. 2018 Sep 1
81 30292140 Metformin Protects against H2O2-Induced Cardiomyocyte Injury by Inhibiting the miR-1a-3p/GRP94 Pathway. 2018 Dec 7 4
82 27167128 Metformin Improves Functional Recovery After Spinal Cord Injury via Autophagy Flux Stimulation. 2017 Jul 7
83 28154203 Metformin Accumulation Correlates with Organic Cation Transporter 2 Protein Expression and Predicts Mammary Tumor Regression In Vivo. 2017 Mar 1
84 28158902 Metformin attenuates albumin-induced alterations in renal tubular cells in vitro. 2017 Dec 8
85 28183442 High-dose metformin (420mg/kg daily p.o.) increases insulin sensitivity but does not affect neointimal thickness in the rat carotid balloon injury model of restenosis. 2017 Mar 2
86 28752417 Metformin Alleviated the Neuronal Oxidative Stress in Hippocampus of Rats under Single Prolonged Stress. 2017 Sep 3
87 29142469 Hypothermic machine perfusion with metformin-University of Wisconsin solution for ex vivo preservation of standard and marginal liver grafts in a rat model. 2017 Oct 28 2
88 26373430 Inhibition of AMPK through Lyn-Syk-Akt enhances FcεRI signal pathways for allergic response. 2016 Feb 2
89 26708162 Cardioprotective effect of metformin in lipopolysaccharide-induced sepsis via suppression of toll-like receptor 4 (TLR4) in heart. 2016 Feb 5 3
90 26845410 Corrigendum: Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats. 2016 Feb 1
91 26960058 Metformin pretreatment enhanced learning and memory in cerebral forebrain ischaemia: the role of the AMPK/BDNF/P70SK signalling pathway. 2016 Oct 5
92 26972495 Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways. 2016 Apr 1
93 26978596 Activation of AMPK Prevents Monocrotaline-Induced Extracellular Matrix Remodeling of Pulmonary Artery. 2016 Mar 9 1
94 26998282 LKB1/AMPK pathway mediates resistin-induced cardiomyocyte hypertrophy in H9c2 embryonic rat cardiomyocytes. 2016 Mar 1
95 27170051 The Effects of Pycnogenol® as Add-on Drug to Metformin Therapy in Diabetic Rats. 2016 Aug 2
96 27379837 Traumatic brain injury decreases AMP-activated protein kinase activity and pharmacological enhancement of its activity improves cognitive outcome. 2016 Oct 1
97 27513844 AMPK Mediates Glucocorticoids Stress-Induced Downregulation of the Glucocorticoid Receptor in Cultured Rat Prefrontal Cortical Astrocytes. 2016 3
98 27756052 AMPK activation by metformin inhibits local innate immune responses in the isolated rat heart by suppression of TLR 4-related pathway. 2016 Nov 4
99 25413451 Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia. 2015 Jun 5
100 25433920 Evidence for organic cation transporter-mediated metformin transport and 5'-adenosine monophosphate-activated protein kinase activation in rat skeletal muscles. 2015 Feb 1