Title : Effects of metformin on the osteogenesis of alveolar BMSCs from diabetic patients and implant osseointegration in rats.

Pub. Date : 2022 May

PMID : 33606350






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1 RESULTS: Metformin increased implant osteointegration in a rat model and promoted the osteogenic capacity of DM-BMSCs via the AMPK/BMP/Smad signalling pathway, and 125 muM was the optimal concentration; however, concentrations over 200 microM, metformin showed an inhibitory effect on DM-BMSCs. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus