Title : Corticosterone induces neurotoxicity in PC12 cells via disrupting autophagy flux mediated by AMPK/mTOR signaling.

Pub. Date : 2020 Feb

PMID : 31423743






1 Functional Relationships(s)
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1 Mechanistically, our results demonstrated that autophagy activation by AMPK activator metformin or mTOR inhibitor rapamycin obviously promotes cell survival and autophagy flux, improved mitochondrial ultrastructure, and reduced expression of Cyt-C and caspase-3 in CORT-induced PC12 cells. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus