Pub. Date : 2020 May 1
PMID : 32249610
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin, an AMP-activated protein kinase (AMPK) activator, has been shown in previous studies to reduce kidney fibrosis in different models of experimental chronic kidney disease (CKD). | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
| 2 | Metformin, an AMP-activated protein kinase (AMPK) activator, has been shown in previous studies to reduce kidney fibrosis in different models of experimental chronic kidney disease (CKD). | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
| 3 | In addition, treatment with metformin was also able to activate kidney AMPK and therefore improve mitochondrial biogenesis. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
| 4 | It was concluded that metformin can arrest the progression of established kidney disease in the Nx model, likely via the activation of AMPK. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |