Title : Metformin Protects against NMDA-Induced Retinal Injury through the MEK/ERK Signaling Pathway in Rats.

Pub. Date : 2021 Apr 23

PMID : 33922757






3 Functional Relationships(s)
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1 The neuroprotective effect of metformin was abolished by compound C, an inhibitor of AMP-activated protein kinase (AMPK). Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
2 The neuroprotective effect of metformin was abolished by compound C, an inhibitor of AMP-activated protein kinase (AMPK). Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
3 These results suggest that metformin protects against NMDA-induced retinal neurotoxicity through activation of the AMPK and MEK/extracellular signal-regulated kinase (ERK) signaling pathways. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus