Title : Decreased efficacy of the ketamine and scopolamine-induced sustained antidepressant-like effects in rats receiving metformin.

Pub. Date : 2022 Apr

PMID : 34850372






3 Functional Relationships(s)
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Protein Name
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1 Metformin activates AMP-activated kinase (AMPK), which inhibits mechanistic target of rapamycin complex 1 (mTORC1) signaling. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
2 Metformin activates AMP-activated kinase (AMPK), which inhibits mechanistic target of rapamycin complex 1 (mTORC1) signaling. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus
3 Notably, ketamine, scopolamine, and metformin all exerted significant antidepressant-like actions, as evidenced by increased AMPK phosphorylation and BDNF expression. Metformin protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus