granzyme A ; Homo sapiens






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1 1989498 The enzymatic activity of human cytotoxic T-lymphocyte granzyme A and cytolysis mediated by cytotoxic T-lymphocytes are potently inhibited by a synthetic antiprotease, FUT-175. Arch Biochem Biophys 1991 Jan 3
2 1998680 Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins. Biochemistry 1991 Feb 26 4
3 2125503 Interaction of chondroitin sulfate with perforin and granzymes of cytolytic T-cells is dependent on pH. Biochemistry 1990 Dec 25 3
4 2788710 Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A. J Exp Med 1989 Sep 1 1
5 3047119 Human cytotoxic lymphocyte tryptase. Its purification from granules and the characterization of inhibitor and substrate specificity. J Biol Chem 1988 Sep 15 1
6 3262682 Characterization of three serine esterases isolated from human IL-2 activated killer cells. J Immunol 1988 Nov 1 2
7 6432749 Human whole-blood oxygen affinity: effect of carbon monoxide. J Appl Physiol Respir Environ Exerc Physiol 1984 Jul 2
8 6813948 Determination of interdependent ligand effects on human red cell oxygen affinity. Scand J Clin Lab Invest 1982 Jun 3
9 8276128 1,25(OH)2D3 increases cytotoxicity and exocytosis in lymphokine-activated killer cells. Mol Cell Endocrinol 1993 Oct 4
10 8432729 Granzymes A and B are targeted to the lytic granules of lymphocytes by the mannose-6-phosphate receptor. J Cell Biol 1993 Feb 1
11 8598480 Activation of NK cells by CC chemokines. Chemotaxis, Ca2+ mobilization, and enzyme release. J Immunol 1996 Jan 1 1
12 8621589 Expression of human recombinant granzyme A zymogen and its activation by the cysteine proteinase cathepsin C. J Biol Chem 1996 Apr 19 1
13 8835202 Activity of granzyme A, a serine protease in the killing granules of cytotoxic T lymphocytes, is reduced in cells from HIV-infected hemophiliacs. AIDS Res Hum Retroviruses 1996 Feb 10 1
14 8954610 Association of serine protease with the rise of intracellular calcium in cytotoxic T lymphocytes. Cell Immunol 1996 Dec 15 1
15 9256474 Recombinant human granzyme A binds to two putative HLA-associated proteins and cleaves one of them. Proc Natl Acad Sci U S A 1997 Aug 19 3
16 9647220 A role for heat shock protein 27 in CTL-mediated cell death. J Immunol 1998 Jul 1 1
17 9836602 Oxyanion-mediated inhibition of serine proteases. Biochemistry 1998 Dec 1 1
18 10789681 Involvement of FK506-sensitive and insensitive granule exocytosis pathways in perforin-dependent target cell lysis mediated by a CD8+ CTL clone. Immunol Lett 2000 Apr 3 2
19 11069717 Cationic lipid gene transfer of an IL-2 transgene leads to activation of natural killer cells in a SCID mouse human tumor xenograft. Cell Immunol 2000 Sep 15 4
20 12819769 The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity. Nat Struct Biol 2003 Jul 3
21 12819770 Crystal structure of the apoptosis-inducing human granzyme A dimer. Nat Struct Biol 2003 Jul 2
22 15286980 Molecular understanding of oxygen-tension and patient-variability effects on ex vivo expanded T cells. Biotechnol Bioeng 2004 Aug 20 2
23 15507639 Granzymes and caspase 3 play important roles in control of gammaherpesvirus latency. J Virol 2004 Nov 1
24 15780992 Granzyme A induces caspase-independent mitochondrial damage, a required first step for apoptosis. Immunity 2005 Mar 4
25 16002202 Dimethyl 2,2-dichlorovinyl phosphate (DDVP) markedly decreases the expression of perforin, granzyme A and granulysin in human NK-92CI cell line. Toxicology 2005 Sep 15 1
26 16328022 Influence of pentoxifylline on natural cytotoxicity and expression of granzymes and PI-9, a specific granzyme B inhibitor. Int J Mol Med 2006 Jan 2
27 16850582 [Characteristics of natural killer cell]. Srp Arh Celok Lek 2006 Jan-Feb 1
28 16873099 Phytoncides (wood essential oils) induce human natural killer cell activity. Immunopharmacol Immunotoxicol 2006 1
29 17180578 Glucocorticoid-induced alternative promoter usage for a novel 5' variant of granzyme A. J Hum Genet 2007 2
30 17244155 Expression of granzyme A in human polymorphonuclear neutrophils. Immunology 2007 Jun 1
31 17405914 Control of human herpes virus type 8-associated diseases by NK cells. Ann N Y Acad Sci 2007 Jan 1
32 18063463 DDVP markedly decreases the expression of granzyme B and granzyme 3/K in human NK cells. Toxicology 2008 Jan 20 2
33 18485862 Granzyme a, a stealth killer in the mitochondrion. Cell 2008 May 16 1
34 18485875 Granzyme A cleaves a mitochondrial complex I protein to initiate caspase-independent cell death. Cell 2008 May 16 9
35 19506301 The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1. Blood 2009 Aug 6 3
36 19646207 Recruitment of CD8(+) T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis. Parasite Immunol 2009 Aug 2
37 20451619 Identification and characterization of common carp (Cyprinus carpio L.) granzyme A/K, a cytotoxic cell granule-associated serine protease. Fish Shellfish Immunol 2010 Sep 1
38 20536557 Granzyme A activates another way to die. Immunol Rev 2010 May 2
39 21310942 Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells. Carcinogenesis 2011 May 3
40 22089193 Increased granzyme levels in cytotoxic T lymphocytes are associated with disease severity in emergency department patients with severe sepsis. Shock 2012 Mar 2
41 23017670 CD4+ CD25+ Foxp3+ IFNγ+ CD178+ human induced Treg (iTreg) contribute to suppression of alloresponses by apoptosis of responder cells. Hum Immunol 2013 Feb 1
42 25921628 Effect of carbamate pesticides on perforin, granzymes A-B-3/K, and granulysin in human natural killer cells. Int J Immunopathol Pharmacol 2015 Sep 3
43 26032366 Histone H3 is Digested by Granzyme A During Compromised Cell Death in the Raji Cells. J Microbiol Biotechnol 2015 Sep 3
44 26051682 Granzyme A as a potential biomarker of Mycobacterium tuberculosis infection and disease. Immunol Lett 2015 Aug 1
45 27439606 Histone H4 is cleaved by granzyme A during staurosporine-induced cell death in B-lymphoid Raji cells. BMB Rep 2016 Oct 5
46 27756784 TGFβR1 Blockade with Galunisertib (LY2157299) Enhances Anti-Neuroblastoma Activity of the Anti-GD2 Antibody Dinutuximab (ch14.18) with Natural Killer Cells. Clin Cancer Res 2017 Feb 1 1
47 27894665 Modulatory effects of curcumin on apoptosis and cytotoxicity-related molecules in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients. Biomed Pharmacother 2017 Jan 2
48 28333940 Distinct transcriptome profiles of Gag-specific CD8+ T cells temporally correlated with the protection elicited by SIVΔnef live attenuated vaccine. PLoS One 2017 1
49 30597040 Minocycline Immunomodulates via Sonic Hedgehog Signaling and Apoptosis and Has Direct Potency Against Drug-Resistant Tuberculosis. J Infect Dis 2019 Feb 23 1
50 31173374 Leishmania infantum induces expression of the negative regulatory checkpoint, CTLA-4, by human naïve CD8<sup>+</sup> T cells. Parasite Immunol 2019 Sep 1